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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients

Fig. 1

Clinical course of Recipient 1 (a) and Recipient 2 (b). From admission and day of surgery (HTx) to death highlighting the SARS-CoV-2 RNA load (Log10 copies/ml), the ward and ICU length of stay, diagnostic and therapeutic interventions such as chest CT, myocardial biopsy, BAL, initiation of antibiotics, and HCQ. a MM was withheld on POD 16. The clinical deterioration observed on POD 14 was close to the peak of the viral load observed on POD 16. b MM was withheld on POD 20. We can see that the deterioration of the patient’s clinical status on POD 19 coincides with a peak of the viral load. The SARS-CoV-2 RNA load is expressed by log10 copies per milliliter. Two RT-PCR assays were used due to a change in the testing method of the laboratory. The first target is the E and RdRP gene (Corman V.) The second test is the automated Cobas© SARS-CoV-2 molecular test (Cobas 6800 Roche) targeting the E and ORF1ab genes. Only the E gene is illustrated in the figure. ABt, antibiotics; BAL, bronchoalveolar lavage; Chest CT, chest computed tomography; HTx, heart transplantation; HCQ, hydroxychloroquine; ICU, intensive care unit; MM, mycophenolate mofetil; POD, postoperative day; RT-PCR, reverse transcriptase polymerase chain reaction

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