Table 3 Laboratory data of 286 inpatients at admission and at a secondary time point between 48 and 96 h of admission. Median and interquartile ranges are presented. The P value is calculated between patients who survived and did not survive. aPTT, activated partial thromboplastin time; Alk Phosphatase, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CI, confidence interval; CRP, C-reactive protein; INR, international normalized ratio; LDH, lactate dehydrogenase; PT, prothrombin time

Hemoglobin

(12–16 g/dL)

At admission (286)

12.3 (11.0–14.0)

12.7 (11.3–14.3)

−0.9 - 0.1

0.13

48–96 h (228)

12.0 (10.15–13.1)

11.7 (10.5–13.3)

−0.6 - 0.5

0.83

Leukocyte count

(3.5–10.8 K/μL)

At admission (285)

7.2 (5.4–9.3)

8.6 (6.4–11.3)

−2.3 - -0.7

< 0.001

48–96 h (228)

6.5 (5.1–9.4)

10.6 (7.8–14.3)

−4.9 - -2.7

< 0.001

Neutrophil Count

(1.7–7 K/μL)

on admission (270)

5.8 (3.8–7.8)

7.3 (4.8–10.0)

− 2.3 - -0.8

< 0.001

48–96 h (205)

5.4 (3.4–7.6)

8.9 (6.4–12.5)

−4.8, − 2.5

< 0.001

Lymphocyte count

(0.9–2.9 K/μL)

on admission (260)

0.9 (0.7–1.1)

0.8 (0.6–1.1)

−5.4e - -5, 0.2

0.04

48–96 h(205)

1.0 (0.8–1.3)

0.8 (0.5–1.2)

0.1–0.3

0.002

Neutrophil Lymphocyte count (NLR)

on admission (260)

5.4 (3.7–8.1)

8.3 (5.3–13.7)

−3.8 - -1.4

< 0.001

48–96 h (204)

4.7 (3.3–7.0)

10.0 (6.06–19.5)

−6.7 - -3.2

< 0.001

Eosinophil count

(0.0–0.8 K/μL)

on admission (255)

0.03 (0.01–0.07)

0.02 (0.01–0.04)

0.002–0.01

< 0.001

48–96 h (203)

0.05 (0.02–0.1)

0.01 (0.01–0.04)

0.01–0.03

< 0.001

Platelet count

(130–400 K/μL)

on admission (283)

204 (158–266)

200 (147–260)

−11.0 - 28

0.40

48–96 h (225)

229 (153–338)

194 (150–280)

− 5.9 - 53.9

0.11

Sodium

(136–145 mmol/L)

on admission (286)

136 (133–138)

136 (132–141)

− 2.0 - 1.0

0.51

48–96 h (237)

138 (136–140)

142 (137–147)

− 5.9 - -2.0

< 0.001

Potassium

(3.5–5.1 mmol/L)

on admission (286)

4.2 (3.8–4.8)

4.4 (3.9–5.0)

− 0.4 - 4.9e-5

0.04

48–96 h (235)

4.3 (4.0–4.6)

4.4 (3.9–5)

− 0.4 - 5.2e-5

0.05

Bicarbonate

(23.0–28.0 mmol/L)

on admission (196)

25 (22–30)

22 (19–26)

1.0–4.9

0.001

48–96 h (143)

24 (21–28)

21 (18–24)

1.6–5.0

<.0.001

Chloride

(98–107 mmol/L)

on admission (285)

100 (94–103)

100 (96–105)

− 3.9 - 3.5e-5

0.09

48–96 h (238)

102 (96–106)

107 (101–113)

− 8.0 - -3.0

< 0.001

Magnesium

(1.9–2.7 mg/dL)

on admission (159)

2 (1.8–2.2)

2.2 (1.9–2.6)

− 0.30 - -2.9e-5

0.014

48–96 h (164)

2.2 (1.8–2.3)

2.4 (2.1–2.7)

− 0.4 - -0.2

< 0.001

BUN

(7–25 mg/dL)

on admission (285)

22 (14–38)

33 (19–54)

− 14.0 - -5.0

< 0.001

48–96 h (235)

20 (14–40)

38 (23–67)

− 22.0 - -10

< 0.001

Serum creatinine

(0.7–1.3 mg/dL)

on admission (286)

1.3 (1.0–2.4)

1.7 (1.2–2.6)

− 0.5 - -0.1

0.008

48–96 h (237)

1.2 (0.8–2.3)

1.6 (1.1–3.1)

−0.6 - -0.1

0.003

Glucose – random

(70–99 mg/dL)

on admission (286)

128 (104–184)

182 (129–275)

− 61.0 - -23.0

< 0.001

48–96 h (240)

103 (84–140)

163 (119–269)

− 72.9 - -35.9

< 0.001

AST

(13–39 μ/L)

on admission (284)

40 (26–65)

52 (38–83)

− 19.0 - -5.0

< 0.001

48–96 h (224)

49 (28–66)

64 (37.7–106.2)

− 29.0 - -8.0

< 0.001

ALT

(7–52 μ/L)

on admission (284)

24 (16–38)

29 (19–44)

− 7.0 - 0.1

0.11

48–96 h (224)

28 (17–52)

34 (22–57)

− 10.0 - 2.0

0.22

Alk Phosphatase

(34–104 U/L)

on admission (284)

64 (49–78)

66 (54–96)

− 15.0 - -1.0

0.02

48–96 h (223)

59 (46–78)

75 (52–111)

− 27.0 - -7.0

< 0.001

Bilirubin

(0.3–1 mg/dL)

on admission (280)

0.5 (0.4–0.8)

0.6 (0.5–0.8)

− 0.1 - 5.0e-5

0.28

48–96 h (219)

0.5 (0.4–0.8)

0.7 (0.5–.9)

− 0.2 - -5.4e-5

0.002

Total protein

(6–8.3 g/dL)

on admission (282)

7 (6.5–7.3)

6.7 (6.4–7.2)

−2.6e-5 - 0.3

0.12

48–96 h (219)

6.2 (5.9–6.6)

6 (5.5–6.7)

− 6.0e-5 - 0.4

0.10

Albumin

(3.5–5.7 g/dL)

on admission (283)

3.6 (3.2–4.0)

3.4 (3.1–3.6)

0.1–0.3

< 0.001

48–96 h (223)

3.0 (2.7–3.2)

2.8 (2.5–3.0)

0.1–0.3

< 0.001

LDH

(14–271 U/L)

on admission (201)

379 (280–500)

551 (411–743)

106.0–22,849

< 0.001

48–96 h (82)

406 (278–553)

638 (444.5–867)

106.9–339.0

< 0.001

CRP

(< 10 mg/L)

on admission (201)

117 (63–197)

180 (128–283)

−97.0 - -36.9

< 0.001

48–96 h (85)

96 (41–185)

283 (188–338)

−200.0 - -88.9

< 0.001

Troponin I

(<=0.15 ng/mL)

on admission (170)

0.03 (0.02–0.12)

0.08 (0.02–0.21)

3.6e-5 - 0.06

0.010

48–96 h (61)

0.11 (0.02–0.26)

0.15 (0.06–0.40)

− 0.03 - 0.18

0.30

Ferritin

(14–233 ng/mL)

on admission (190)

654.5 (303–1151)

955 (539.0–2114.6)

118.5–566.5

0.002

48–96 h (95)

768.5 (439–1821)

1614.1 (499.7–2801.5)

− 37.3, −  1036.7

0.08

Procalcitonin

(0–0.10 ng/mL)

on admission(172)

0.32 (0.10–0.96)

1.03 (0.36–3.78)

0.19–0.88

< 0.001

48–96 h (69)

0.34 (0.25–2.47)

1.68 (0.41–7.35)

4.75e-5 - 2.77

0.049

D-dimer

< 0.4 mcg/ml

on admission (50)

3.3 (1.3–5.2)

1.5 (0.5–5.2)

−1.02 - 2.6

0.39

48–96 h (43)

0.5 (0.5–1.5)

3.0 (1.1–7.5)

− 4.5 - -0.2

< 0.001

aPTT

(25.4–38.6 s)

on admission (126)

29.9 (28.4–32.4)

29.0 (26.9–33.6)

−1.9 - 1.5

0.68

48–96 h (44)

30.7 (28.0–36.2)

31.1 (27.9–39.0)

− 6.3 - 6.3

0.99

PT

(10.8–13.7 s)

on admission (113)

13.0 (12.2–13.7)

13.5 (12.6–15.4)

5.1–1.3

0.04

48–96 h(43)

13.1 (11.9–15.2)

17.2 (13.3–20.2)

4.94e-5 - 6.7

0.04

INR (1 U)

on admission (113)

1.1 (1.0–1.1)

1.1 (1.0–1.3)

− 7.12e-6 - 0.10

0.07

48–96 h (41)

1.0 (1.0–1.2)

1.4 (1.1–1.6)

7.49e-6 - 0.50

0.02