Fig. 4

Potential clinical impact of the predictive nomogram for the proposed intervention. The X-axis indicates that the threshold probability refers to the relative harm and benefit of the proposed intervention; the Y-axis indicates that the standardized net benefit. a. Decision curve analysis for the training cohort. b. Decision curve analysis for the validation cohort. c. Opt-out decision curve analysis for the training cohort. d. Opt-out decision curve analysis for the validation cohort