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Table 4 Frequencies of IFNL3 and IFNL4 haplotypes concerning spontaneous HCV elimination (cases) and persistent HCV infection (controls)

From: Polymorphism rs368234815 of interferon lambda 4 gene and spontaneous clearance of hepatitis C virus in haemodialysis patients: a case-control study

SNPs

Haplotype

Haplotype Frequencies

Case, Control

Frequencies

Chi Square

P Value

Pcorr

Value

OR (95%CI), P Value

OR (95%CI)§, P Value

rs12980275_rs4803217_rs12979860_rs368234815_rs8099917

A_C_C_TT_T

0.562

0.667, 0.485

10.590

0.0011

0.0060

2.294 (1.412–3.727), 0.0007

Reference

G_A_T_∆G_G

0.174

0.102, 0.227

8.543

0.0035

0.0190

0.380 (0.197–0.732), 0.0030

0.326 (0.167–0.638), 0.0008

G_A_T_∆G_T

0.121

0.110, 0.130

0.289

0.5909

1.0000

0.819 (0.411–1.632), 0.5692

0.611 (0.301–1.241), 0.1706

G_C_C_TT_T

0.043

0.037, 0.046

0.164

0.6855

1.0000

0.736 (0.241–2.253), 0.5901

0.543 (0.175–1.685), 0.2847

A_A_T_∆G_T

0.020

0.008, 0.028

1.583

0.2083

0.7840

0.263 (0.030–2.280), 0.1934

0.196 (0.022–1.709), 0.1024

G_A_T_TT_G

0.016

0.015, 0.016

0.013

0.9081

1.0000

0.894 (0.147–5.434), 0.9032

0.652 (0.106–3.997), 0.6415

  1. P-value calculated using the permutation test and a total of 1000 permutations
  2. All other haplotypes pooled together were used as the reference
  3. §The most common haplotype was used as the reference