Gene† | rs no. | HCV RNA positive | HCV RNA negative | A difference in genotype/allele distribution between HCV RNA positive and HCV RNA negative | The probability of spontaneous HCV clearance in the dominant mode of inheritance‡ | The probability of spontaneous HCV clearance in the additive mode of inheritance§ | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | Genotype distribution, n (frequency) | MAF | n | Genotype distribution, n (frequency) | MAF | P trend¶ | P genotype∆ | P allelic∆ | OR, 95% CI | P value∆, sample power | OR, 95% CI | P value∆, sample power | ||
IFNL3 | 12980275 | 91 | AA 25 (27.5) AG 48 (52.7) GG 18 (19.8) | 0.46 | 68 | AA 35 (51.5) AG 26 (38.2) GG 7 (10.3) | 0.29 | 0.003 | 0.007 | 0.002 | 2.8, 1.45–5.43 | 0.002 97% | 3.60, 1.31–9.91 | 0.011 > 99.9% |
IFNL3 | 4803217 | 92 | GG 29 (31.5) GT 48 (52.2) TT 15 (16.3) | 0.42 | 67 | GG 36 (53.7) GT 27 (40.3) TT 4 (6.0) | 0.26 | 0.002 | 0.01 | 0.003 | 2.52, 1.32–4.84 | 0.005 95% | 4.66, 1.39–15.56 | 0.008 > 99.9% |
IFNL4 | 12979860 | 90 | CC 29 (32.2) CT 45 (50.0) TT 16 (17.8) | 0.43 | 67 | CC 36 (53.7) CT 26 (38.8) TT 5 (7.5) | 0.27 | 0.004 | 0.015 | 0.004 | 2.44, 1.27–4.69 | 0.007 93% | 3.97, 1.30–12.14 | 0.012 > 99.9% |
IFNL4 | 368234815 | 93 | TT/TT 29 (31.2) TT/∆G 49 (52.7) ∆G/∆G 15 (16.1) | 0.42 | 68 | TT/TT 37 (54.4) TT/∆G 28 (41.2) ∆G/∆G 3 (4.4) | 0.25 | 0.0009 | 0.004 | 0.001 | 2.63, 1.38–5.04 | 0.003 97% | 6.38, 1.69–24.2 | 0.003 > 99.9% |
IFNL4 | 8099917 | 92 | TT 48 (52.2) GT 38 (41.3) GG 6 (6.5) | 0.27 | 68 | TT 51 (75) GT 17 (25) GG 0 (0) | 0.13 | 0.001 | 0.003# | 0.001 | 2.75, 1.39–5.45 | 0.003 98% | 13.8, 0.76–251.6 | 0.027# > 99.9% |