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Table 3 Associations of IFNL3/IFNL4 polymorphisms with spontaneous HCV clearance in HD patients exposed to HCV

From: Polymorphism rs368234815 of interferon lambda 4 gene and spontaneous clearance of hepatitis C virus in haemodialysis patients: a case-control study

Gene

rs no.

HCV RNA positive

HCV RNA negative

A difference in genotype/allele distribution between HCV RNA positive and HCV RNA negative

The probability of spontaneous HCV clearance in the dominant mode of inheritance

The probability of spontaneous HCV clearance in the additive mode of inheritance§

n

Genotype distribution, n (frequency)

MAF

n

Genotype distribution, n (frequency)

MAF

P trend

P genotype

P allelic

OR, 95% CI

P value, sample power

OR, 95% CI

P value, sample power

IFNL3

 12980275

91

AA 25 (27.5)

AG 48 (52.7)

GG 18 (19.8)

0.46

68

AA 35 (51.5)

AG 26 (38.2)

GG 7 (10.3)

0.29

0.003

0.007

0.002

2.8, 1.45–5.43

0.002

97%

3.60, 1.31–9.91

0.011

> 99.9%

IFNL3

 4803217

92

GG 29 (31.5)

GT 48 (52.2)

TT 15 (16.3)

0.42

67

GG 36 (53.7)

GT 27 (40.3)

TT 4 (6.0)

0.26

0.002

0.01

0.003

2.52, 1.32–4.84

0.005

95%

4.66, 1.39–15.56

0.008

> 99.9%

IFNL4

 12979860

90

CC 29 (32.2)

CT 45 (50.0)

TT 16 (17.8)

0.43

67

CC 36 (53.7)

CT 26 (38.8)

TT 5 (7.5)

0.27

0.004

0.015

0.004

2.44, 1.27–4.69

0.007

93%

3.97, 1.30–12.14

0.012

> 99.9%

IFNL4

368234815

93

TT/TT 29 (31.2)

TT/∆G 49 (52.7)

∆G/∆G 15 (16.1)

0.42

68

TT/TT 37 (54.4)

TT/∆G 28 (41.2)

∆G/∆G 3 (4.4)

0.25

0.0009

0.004

0.001

2.63, 1.38–5.04

0.003

97%

6.38, 1.69–24.2

0.003

> 99.9%

IFNL4

 8099917

92

TT 48 (52.2)

GT 38 (41.3)

GG 6 (6.5)

0.27

68

TT 51 (75)

GT 17 (25)

GG 0 (0)

0.13

0.001

0.003#

0.001

2.75, 1.39–5.45

0.003

98%

13.8, 0.76–251.6

0.027#

> 99.9%

  1. † − chromosomal localization of IFNL3 and IFNL4 genes towards the forward strand is shown
  2. ‡ − genotypes with the variant alleles as reference
  3. § – the variant homozygosity as reference
  4. ¶ - Cochran-Armitage Trend Test
  5. ∆ - Pearson’s Chi-squared test
  6. # - Fisher’s exact test