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Table 3 Associations of IFNL3/IFNL4 polymorphisms with spontaneous HCV clearance in HD patients exposed to HCV

From: Polymorphism rs368234815 of interferon lambda 4 gene and spontaneous clearance of hepatitis C virus in haemodialysis patients: a case-control study

Gene rs no. HCV RNA positive HCV RNA negative A difference in genotype/allele distribution between HCV RNA positive and HCV RNA negative The probability of spontaneous HCV clearance in the dominant mode of inheritance The probability of spontaneous HCV clearance in the additive mode of inheritance§
n Genotype distribution, n (frequency) MAF n Genotype distribution, n (frequency) MAF P trend P genotype P allelic OR, 95% CI P value, sample power OR, 95% CI P value, sample power
IFNL3  12980275 91 AA 25 (27.5)
AG 48 (52.7)
GG 18 (19.8)
0.46 68 AA 35 (51.5)
AG 26 (38.2)
GG 7 (10.3)
0.29 0.003 0.007 0.002 2.8, 1.45–5.43 0.002
97%
3.60, 1.31–9.91 0.011
> 99.9%
IFNL3  4803217 92 GG 29 (31.5)
GT 48 (52.2)
TT 15 (16.3)
0.42 67 GG 36 (53.7)
GT 27 (40.3)
TT 4 (6.0)
0.26 0.002 0.01 0.003 2.52, 1.32–4.84 0.005
95%
4.66, 1.39–15.56 0.008
> 99.9%
IFNL4  12979860 90 CC 29 (32.2)
CT 45 (50.0)
TT 16 (17.8)
0.43 67 CC 36 (53.7)
CT 26 (38.8)
TT 5 (7.5)
0.27 0.004 0.015 0.004 2.44, 1.27–4.69 0.007
93%
3.97, 1.30–12.14 0.012
> 99.9%
IFNL4 368234815 93 TT/TT 29 (31.2)
TT/∆G 49 (52.7)
∆G/∆G 15 (16.1)
0.42 68 TT/TT 37 (54.4)
TT/∆G 28 (41.2)
∆G/∆G 3 (4.4)
0.25 0.0009 0.004 0.001 2.63, 1.38–5.04 0.003
97%
6.38, 1.69–24.2 0.003
> 99.9%
IFNL4  8099917 92 TT 48 (52.2)
GT 38 (41.3)
GG 6 (6.5)
0.27 68 TT 51 (75)
GT 17 (25)
GG 0 (0)
0.13 0.001 0.003# 0.001 2.75, 1.39–5.45 0.003
98%
13.8, 0.76–251.6 0.027#
> 99.9%
  1. † − chromosomal localization of IFNL3 and IFNL4 genes towards the forward strand is shown
  2. ‡ − genotypes with the variant alleles as reference
  3. § – the variant homozygosity as reference
  4. ¶ - Cochran-Armitage Trend Test
  5. ∆ - Pearson’s Chi-squared test
  6. # - Fisher’s exact test