Polymorphism rs368234815 of interferon lambda 4 gene and spontaneous clearance of hepatitis C virus in haemodialysis patients: a case-control study

Table 2 IFNL4 rs368234815 polymorphic variants and HCV RNA positivity in HD patients exposed to HCV

Genotypes, MAF	HCV RNA positive patients (n = 93) n, % of all	HCV RNA negative patients (n = 68) n, % of all	Odds ratio (95% CI), P-value^†
IFNL4 rs368234815 (n = 161, P_trend^† = 0.0009, P_genotype^‡ = 0.004)
TT/TT	29 (31.2)	37 (54.4)	Reference
TT/∆G	49 (52.7)	28 (41.2)	2.233 (1.140–4.373), 0.02^§
∆G/∆G	15 (16.1)	3 (4.4)	6.379 (1.685–24.16), 0.003
TT/∆G + ∆G/∆G vs TT/TT	64 (68.8)	31 (45.6)	2.634 (1.377–5.037), 0.003
∆G/∆G vs TT/TT + TT/∆G	15 (16.1)	3 (4.4)	4.167 (1.156–15.02), 0.02^§
MAF	(0.42)	(0.25)	2.215 (1.364–3.597), 0.001

P for HWE: All: 0.527, HCV RNA positive: 0.451, HCV RNA negative: 0.419
Abbreviations: HCV hepatitis C virus, IFNL4 – interferon-λ4 gene, HD haemodialysis, MAF minor allele frequency, RNA ribonucleic acid
^† − Cochran-Armitage trend Test; ^‡ − Pearson’s Chi-squared test; § – not significant after the Bonferroni correction (P > 0.007)

ISSN: 1471-2334