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Table 2 IFNL4 rs368234815 polymorphic variants and HCV RNA positivity in HD patients exposed to HCV

From: Polymorphism rs368234815 of interferon lambda 4 gene and spontaneous clearance of hepatitis C virus in haemodialysis patients: a case-control study

Genotypes, MAF HCV RNA positive patients (n = 93)
n, % of all
HCV RNA negative patients (n = 68)
n, % of all
Odds ratio (95% CI),
P-value
IFNL4 rs368234815 (n = 161, Ptrend = 0.0009, Pgenotype = 0.004)
 TT/TT 29 (31.2) 37 (54.4) Reference
 TT/∆G 49 (52.7) 28 (41.2) 2.233 (1.140–4.373), 0.02§
 ∆G/∆G 15 (16.1) 3 (4.4) 6.379 (1.685–24.16), 0.003
 TT/∆G + ∆G/∆G vs TT/TT 64 (68.8) 31 (45.6) 2.634 (1.377–5.037), 0.003
 ∆G/∆G vs TT/TT + TT/∆G 15 (16.1) 3 (4.4) 4.167 (1.156–15.02), 0.02§
 MAF (0.42) (0.25) 2.215 (1.364–3.597), 0.001
  1. P for HWE: All: 0.527, HCV RNA positive: 0.451, HCV RNA negative: 0.419
  2. Abbreviations: HCV hepatitis C virus, IFNL4 – interferon-λ4 gene, HD haemodialysis, MAF minor allele frequency, RNA ribonucleic acid
  3.  − Cochran-Armitage trend Test;  − Pearson’s Chi-squared test; § – not significant after the Bonferroni correction (P > 0.007)