Table 4 Treatment characteristics associated with sepsis in patients with cellulitis
From: Factors associated with sepsis development in 606 Spanish adult patients with cellulitis
All n = 606 | No sepsis (n = 541) | Sepsis (n = 65) | P value | |
|---|---|---|---|---|
Treatment before admission | ||||
Yes | 237 (39.1%) | 218 (40.3%) | 19 (29.2%) | 0.08 |
No | 369 (60.9%) | 323 (59.7%) | 46 (70.8%) | |
Initial treatment at admission | ||||
Single antibiotic | 381 (62.9%) | 347 (64.1%) | 34 (52.3%) | 0.06 |
> 1 antibiotic | 225 (37.1%) | 194 (35.9%) | 31 (47.7%) | |
Amoxicillin-clavulanate monotherapy | ||||
Yes | 259 (42.7%) | 231 (42.7%) | 28 (43.1%) | 1 |
No | 347 (57.3%) | 310 (57.3%) | 37 (56.9%) | |
Change of the initial regimen | ||||
Yes | 184 (30.4%) | 148 (27.4%) | 36 (55.4%) | < 0.0001 |
No | 422 (69.6%) | 393 (72.6%) | 29 (44.6%) | |
Reason for change a | ||||
Culture | 57 (31.0%) | 46 (31.1%) | 11 (30.6%) | 0.3 |
Poor response | 55 (29.9%) | 40 (27.0%) | 15 (41.7%) | |
Toxicity | 11 (6.0%) | 9 (6.1%) | 2 (5.6%) | |
Others | 61 (33.2%) | 53 (35.8%) | 8 (22.2%) | |
Days until change a | 3.49 (3.16–3.85) | 3.40 (3.05–3.79) | 3.86 (3.02–4.94) | 0.3 |
Treatment after change a | ||||
Single antibiotic | 86 (46.7%) | 71 (48.0%) | 15 (41.7%) | 0.5 |
> 1 antibiotic | 98 (53.3%) | 77 (52.0%) | 21 (58.3%) | |
Antibiotic treatment after discharge | ||||
Yes | 504 (85.1%) | 453 (84.8%) | 51 (87.9%) | 0.5 |
No | 88 (14.9%) | 81 (15.2%) | 7 (12.1%) | |
Treatment after discharge | ||||
Single antibiotic | 407 (80.8%) | 368 (81.2%) | 39 (76.5%) | 0.4 |
> 1 antibiotic | 97 (19.2%) | 85 (18.8%) | 12 (23.5%) | |
Total number of antibiotics used | 1.59 (1.53–1.65) | 1.55 (1.49–1.61) | 2.02 (1.78–2.28) | < 0.0001 |
Total number of antibiotics used | ||||
1 | 289 (47.7%) | 271 (50.1%) | 18 (27.7%) | 0.0002 |
2 | 191 (31.5%) | 169 (31.2%) | 22 (33.8%) | |
3 | 89 (14.7%) | 74 (13.7%) | 15 (23.1%) | |
4 | 35 (5.8%) | 25 (4.6%) | 10 (15.4%) | |
5 | 2 (0.3%) | 2 (0.4%) | 0 (0.0%) | |
Days of IV antibiotic treatment | 6.14 (5.78–6.52) | 6.00 (5.63–6.38) | 7.48 (6.05–9.26) | 0.03 |
Total days of antibiotic treatment | 13.27 (12.70–13.87) | 13.11 (12.54–13.71) | 14.72 (12.39–17.50) | 0.19 |
Surgical treatment | ||||
Yes | 81 (13.4%) | 66 (12.2%) | 15 (23.1%) | 0.01 |
No | 525 (86.6%) | 475 (87.8%) | 50 (76.9%) | |