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Table 4 Treatment characteristics associated with sepsis in patients with cellulitis

From: Factors associated with sepsis development in 606 Spanish adult patients with cellulitis

 All
n = 606
No sepsis
(n = 541)
Sepsis
(n = 65)
P value
Treatment before admission
 Yes237 (39.1%)218 (40.3%)19 (29.2%)0.08
 No369 (60.9%)323 (59.7%)46 (70.8%) 
Initial treatment at admission
 Single antibiotic381 (62.9%)347 (64.1%)34 (52.3%)0.06
  > 1 antibiotic225 (37.1%)194 (35.9%)31 (47.7%) 
Amoxicillin-clavulanate monotherapy
 Yes259 (42.7%)231 (42.7%)28 (43.1%)1
 No347 (57.3%)310 (57.3%)37 (56.9%) 
Change of the initial regimen
 Yes184 (30.4%)148 (27.4%)36 (55.4%)< 0.0001
 No422 (69.6%)393 (72.6%)29 (44.6%) 
Reason for change a
 Culture57 (31.0%)46 (31.1%)11 (30.6%)0.3
 Poor response55 (29.9%)40 (27.0%)15 (41.7%) 
 Toxicity11 (6.0%)9 (6.1%)2 (5.6%) 
 Others61 (33.2%)53 (35.8%)8 (22.2%) 
Days until change a3.49 (3.16–3.85)3.40 (3.05–3.79)3.86 (3.02–4.94)0.3
Treatment after change a
 Single antibiotic86 (46.7%)71 (48.0%)15 (41.7%)0.5
  > 1 antibiotic98 (53.3%)77 (52.0%)21 (58.3%) 
Antibiotic treatment after discharge
 Yes504 (85.1%)453 (84.8%)51 (87.9%)0.5
 No88 (14.9%)81 (15.2%)7 (12.1%) 
Treatment after discharge
 Single antibiotic407 (80.8%)368 (81.2%)39 (76.5%)0.4
  > 1 antibiotic97 (19.2%)85 (18.8%)12 (23.5%) 
Total number of antibiotics used1.59 (1.53–1.65)1.55 (1.49–1.61)2.02 (1.78–2.28)< 0.0001
Total number of antibiotics used
 1289 (47.7%)271 (50.1%)18 (27.7%)0.0002
 2191 (31.5%)169 (31.2%)22 (33.8%) 
 389 (14.7%)74 (13.7%)15 (23.1%) 
 435 (5.8%)25 (4.6%)10 (15.4%) 
 52 (0.3%)2 (0.4%)0 (0.0%) 
Days of IV antibiotic treatment6.14 (5.78–6.52)6.00 (5.63–6.38)7.48 (6.05–9.26)0.03
Total days of antibiotic treatment13.27 (12.70–13.87)13.11 (12.54–13.71)14.72 (12.39–17.50)0.19
Surgical treatment
 Yes81 (13.4%)66 (12.2%)15 (23.1%)0.01
 No525 (86.6%)475 (87.8%)50 (76.9%) 
  1. Values are expressed as mean (95% CI) or % as appropriate
  2. a Only in patients who underwent treatment modification respect to the initial regimen