From: Factors associated with sepsis development in 606 Spanish adult patients with cellulitis
All n = 606 | No sepsis (n = 541) | Sepsis (n = 65) | P value | |
---|---|---|---|---|
Demography & anthropometry | ||||
Gender | ||||
Male | 314 (51.8%) | 276 (51.0%) | 38 (58.5%) | 0.3 |
Female | 292 (48.2%) | 265 (49.0%) | 27 (41.5%) | |
Age (years) | 63.43 (61.85–65.05) | 63.42 (61.76–65.12) | 63.53 (58.29–69.22) | 1 |
Body mass index (kg/m2) | ||||
(n = 350) | 30.00 (29.25–30-77) | 30.05 (29.28–30.83) | 29.58 (26.73–32.73) | 0.7 |
Predisposing factors / comorbidities | ||||
Prior cellulitis | ||||
Yes | 156 (25.7%) | 139 (25.7%) | 17 (26.2%) | 0.9 |
No | 450 (74.3%) | 402 (74.3%) | 48 (73.8%) | |
Episodes of prior cellulitis | ||||
(Only if prior cellulitis) | 1.72 (1.56–1.90) | 1.71 (1.54–1.89) | 1.86 (1.32–2.61) | 0.6 |
Episodes of prior cellulitis | ||||
0 | 450 (74.3%) | 402 (74.3%) | 48 (73.8%) | 0.4 |
1 | 79 (13.0%) | 71 (13.1%) | 8 (12.3%) | |
2 | 27 (4.5%) | 24 (4.4%) | 3 (4.6%) | |
3 | 26 (4.3%) | 25 (4.6%) | 1 (1.5%) | |
4 or more | 24 (4.0%) | 19 (3.5%) | 5 (7.7%) | |
Location of prior cellulitis | ||||
Same location | 143 (91.7%) | 129 (92.8%) | 14 (82.4%) | 0.15 |
Other locations | 13 (8.3%) | 10 (7.2%) | 3 (17.6%) | |
Prior wounds | ||||
Yes | 332 (54.8%) | 295 (54.5%) | 37 (56.9%) | 0.7 |
No | 274 (45.2%) | 54.5% (45.5%) | 28 (43.1%) | |
Type of wound | ||||
None | 274 (45.2%) | 246 (45.5%) | 28 (43.1%) | 0.8 |
Skin ulcer | 110 (18.2%) | 96 (17.7%) | 14 (21.5%) | |
Non-surgical trauma | 108 (17.8%) | 94 (17.4%) | 14 (21.5%) | |
Surgical | 34 (5.6%) | 32 (5.9%) | 2 (3.1%) | |
Animal bite | 12 (2.0%) | 12 (2.2%) | 0 (0.0%) | |
Injection | 11 (1.8%) | 9 (1.7%) | 2 (3.1%) | |
Arthropod bite | 11 (1.8%) | 10 (1.8%) | 1 (1.5%) | |
Others | 46 (7.6%) | 42 (7.8%) | 4 (6.2%) | |
Prior skin lesions | ||||
Yes | 182 (30.0%) | 164 (30.3%) | 18 (27.7%) | 0.7 |
No | 424 (70.0%) | 377 (69.7%) | 47 (72.3%) | |
Diabetes | ||||
Yes | 153 (25.2%) | 131 (24.2%) | 22 (33.8%) | 0.09 |
No | 453 (74.8%) | 410 (75.8%) | 43 (66.2%) | |
Varices | ||||
Yes | 124 (20.5%) | 112 (20.7%) | 12(18.5%) | 0.7 |
No | 482 (79.5%) | 429 (79.3%) | 53 (81.5%) | |
Prior deep venous thrombosis | ||||
Yes | 23 (3.8%) | 21 (3.9%) | 2 (3.1%) | 0.9 |
No | 583 (95.9%) | 520 (96.1%) | 63 (96.9%) | |
Edema / lymphedema | ||||
Yes | 168 (27.7%) | 151 (27.9%) | 17 (26.2%) | 0.8 |
No | 438 (72.3%) | 390 (72.1%) | 48 (73.8%) | |
Heart failure | ||||
Yes | 101 (16.7%) | 90 (16.6%) | 11 (16.9%) | 1 |
No | 505 (83.3%) | 451 (83.4%) | 54 (83.1%) | |
Obesity | ||||
Yes | 229 (37.8%) | 208 (38.4%) | 21 (32.3%) | 0.3 |
No | 377 (62.2%) | 333 (61.6%) | 44 (67.7%) | |
Immunosuppression | ||||
Yes | 70 (11.6%) | 62 (11.5%) | 8 (12.3%) | 0.8 |
No | 536 (88.4%) | 479 (88.5%) | 57 (87.7%) | |
Intravenous drug use | ||||
Yes | 7 (1.2%) | 7 (1.3%) | 0 (0.0%) | 1 |
No | 599 (98.8%) | 534 (98.7%) | 65 (100%) | |
HIV infection | ||||
Yes | 10 (1.7%) | 10 (1.8%) | 0 (0.0%) | 0.6 |
No | 596 (98.3%) | 531 (98.2%) | 65 (100%) | |
Other comorbidities | ||||
Yes | 452 (74.6%) | 398 (73.6%) | 54 (83.1%) | 0.096 |
No | 154 (25.4%) | 143 (26.4%) | 11 (16.9%) |