Table 2 TNF-α circulating levelsa according to the genotypes of investigated TNF-α polymorphisms
From: Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression
Genotype | Sepsis subgroup | Septic shock subgroup | P value | |
|---|---|---|---|---|
TNF-α -308G/A | GG | 41.31 (10.21–207.1) | 57.28 (10.21–207.5) | 0.01 |
AG | 44.09 (20.14–141.5) | 57.28 (12.48–186.3) | ns | |
AA | 47.68 (10.21–85.14) | – | – | |
AA + AG | 44.09 (10.21–141.5) | 57.28 (12.48–186.3) | ns | |
Allele | G | 42.94 (10.21–207.1) | 57.28 (10.21–207.5) | 0.0007 |
A | 44.09 (10.21–141.5) | 57.28 (12.48–186.3) | 0.07 | |
TNF-α -238G/A | GG | 42.58 (10.21–207.1) | 57.28 (10.21–207.5) | 0.008 |
AG | 62.2 (20.14–72.69) | 63.6 (44.39–73.39) | ns | |
Allele | G | 42.9 (10.21–207.1) | 57.3 (10.21–207.5) | 0.0005 |
A | 62.2 (20.14–72.69) | 63.6 (44.4–73.4) | 0.57 | |
TNF-α -376G/A | GG | 42.58 (10.21–207.1) | 57.28 (10.21–207.5) | 0.002 |
AG | – | 63.6 (44.39–73.39) | – | |
Allele | G | 42.9 (10.21–207.1) | 57.3 (10.21–207.5) | 0.0005 |
A | 67.5 (10.21–54.2) | 63.3 (44.4–73.4) | 0.30 | |
TNF-α +489G/A | GG | 44.09 (10.21–207.1) | 57.09 (10.21–207.5) | ns |
AG | 33.45 (10.21–175.2) | 59.04 (26.76–147.1) | ns | |
AA | 38.95 (25.26–48.71) | – | – | |
AA + AG | 36.2 (10.21–175.2) | 59.04 (26.7–147.1) | ns | |
Allele | G | 43.3 (10.21–207.1) | 57.3 (10.21–207.5) | 0.001 |
A | 36.2 (10.21–175.2) | 59.04 (26.7–147.1) | 0.01 |