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Table 2 TNF-α circulating levelsa according to the genotypes of investigated TNF-α polymorphisms

From: Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression

 GenotypeSepsis subgroupSeptic shock subgroupP value
TNF-α -308G/AGG41.31 (10.21–207.1)57.28 (10.21–207.5)0.01
AG44.09 (20.14–141.5)57.28 (12.48–186.3)ns
AA47.68 (10.21–85.14)
AA + AG44.09 (10.21–141.5)57.28 (12.48–186.3)ns
AlleleG42.94 (10.21–207.1)57.28 (10.21–207.5)0.0007
A44.09 (10.21–141.5)57.28 (12.48–186.3)0.07
TNF-α -238G/AGG42.58 (10.21–207.1)57.28 (10.21–207.5)0.008
AG62.2 (20.14–72.69)63.6 (44.39–73.39)ns
AlleleG42.9 (10.21–207.1)57.3 (10.21–207.5)0.0005
A62.2 (20.14–72.69)63.6 (44.4–73.4)0.57
TNF-α -376G/AGG42.58 (10.21–207.1)57.28 (10.21–207.5)0.002
AG63.6 (44.39–73.39)
AlleleG42.9 (10.21–207.1)57.3 (10.21–207.5)0.0005
A67.5 (10.21–54.2)63.3 (44.4–73.4)0.30
TNF-α +489G/AGG44.09 (10.21–207.1)57.09 (10.21–207.5)ns
AG33.45 (10.21–175.2)59.04 (26.76–147.1)ns
AA38.95 (25.26–48.71)
AA + AG36.2 (10.21–175.2)59.04 (26.7–147.1)ns
AlleleG43.3 (10.21–207.1)57.3 (10.21–207.5)0.001
A36.2 (10.21–175.2)59.04 (26.7–147.1)0.01
  1. ns Non-significance
  2. aPlasma level (pg/mL), expressed as median (range), p: Septic shock group vs sepsis subgroup, Mann-Whitney test