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Table 1 Genotype and allele frequencies of TNF-α +489G/A gene polymorphisms in control and septic patient group and subgroups

From: Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression

Genotype/ allele

Study group

n (%)

Septic shock

n (%)

Sepsis

n (%)

Control

n (%)

pa; OR

(95% CI)

pb; OR

(95% CI)

pc; OR

(95% CI)

AA

3 (1.84)

0 (0.0)

3 (3.1)

15 (6.5)

0.01; 0.22 (0.06–0.8)

0.26; 0.18 (0.009–3.72)

0.01; 0.08 (0.009–0.44)

AG

44 (26.99)

15 (23.1)

29 (29.6)

85 (36.6)

0.01; 0.58 (0.37–0.91)

0.36; 0.68 (0.33–1.40)

0.01; 0.46 (0.24–0.88)

GG

116 (71.16)

50 (76.9)

66 (67.3)

132 (56.9)

Reference

Reference

Reference

AA + AG

47 (28.83)

15 (23.1)

32 (32.7)

100 (43.1)

0.004; 0.53 (0.34–0.82)

0.21; 0.61 (0.30–1.26)

0.003; 0.39 (0.21–0.74)

Allele G

276 (84.7)

115 88.5)

161 (82.1)

349 (75.2)

Reference

Reference

Reference

Allele A

50 (13.33)

15 (11.5)

35 (17.9)

115 (24.8)

0.001; 0.54 (0.38–0.79)

0.12; 0.60 (0.31–1.15)

0.001; 0.39 (0.22–0.70)

HWE Test

0.61

0.29

0.93

0.68

   
  1. OR Odds ratio, CI Confidence interval, HWE Hardy-Weinberg equilibrium
  2. pa: p values for individual genotypes in study group vs control; pb: p values for individual genotypes in sepsis subgroup vs septic shock subgroup; pc: p values for individual genotypes in septic shock subgroup vs control