From: Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression
Genotype/ allele | Study group n (%) | Septic shock n (%) | Sepsis n (%) | Control n (%) | pa; OR (95% CI) | pb; OR (95% CI) | pc; OR (95% CI) |
---|---|---|---|---|---|---|---|
AA | 3 (1.84) | 0 (0.0) | 3 (3.1) | 15 (6.5) | 0.01; 0.22 (0.06–0.8) | 0.26; 0.18 (0.009–3.72) | 0.01; 0.08 (0.009–0.44) |
AG | 44 (26.99) | 15 (23.1) | 29 (29.6) | 85 (36.6) | 0.01; 0.58 (0.37–0.91) | 0.36; 0.68 (0.33–1.40) | 0.01; 0.46 (0.24–0.88) |
GG | 116 (71.16) | 50 (76.9) | 66 (67.3) | 132 (56.9) | Reference | Reference | Reference |
AA + AG | 47 (28.83) | 15 (23.1) | 32 (32.7) | 100 (43.1) | 0.004; 0.53 (0.34–0.82) | 0.21; 0.61 (0.30–1.26) | 0.003; 0.39 (0.21–0.74) |
Allele G | 276 (84.7) | 115 88.5) | 161 (82.1) | 349 (75.2) | Reference | Reference | Reference |
Allele A | 50 (13.33) | 15 (11.5) | 35 (17.9) | 115 (24.8) | 0.001; 0.54 (0.38–0.79) | 0.12; 0.60 (0.31–1.15) | 0.001; 0.39 (0.22–0.70) |
HWE Test | 0.61 | 0.29 | 0.93 | 0.68 |