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Table 1 Genotype and allele frequencies of TNF-α +489G/A gene polymorphisms in control and septic patient group and subgroups

From: Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression

Genotype/ alleleStudy group
n (%)
Septic shock
n (%)
Sepsis
n (%)
Control
n (%)
pa; OR
(95% CI)
pb; OR
(95% CI)
pc; OR
(95% CI)
AA3 (1.84)0 (0.0)3 (3.1)15 (6.5)0.01; 0.22 (0.06–0.8)0.26; 0.18 (0.009–3.72)0.01; 0.08 (0.009–0.44)
AG44 (26.99)15 (23.1)29 (29.6)85 (36.6)0.01; 0.58 (0.37–0.91)0.36; 0.68 (0.33–1.40)0.01; 0.46 (0.24–0.88)
GG116 (71.16)50 (76.9)66 (67.3)132 (56.9)ReferenceReferenceReference
AA + AG47 (28.83)15 (23.1)32 (32.7)100 (43.1)0.004; 0.53 (0.34–0.82)0.21; 0.61 (0.30–1.26)0.003; 0.39 (0.21–0.74)
Allele G276 (84.7)115 88.5)161 (82.1)349 (75.2)ReferenceReferenceReference
Allele A50 (13.33)15 (11.5)35 (17.9)115 (24.8)0.001; 0.54 (0.38–0.79)0.12; 0.60 (0.31–1.15)0.001; 0.39 (0.22–0.70)
HWE Test0.610.290.930.68   
  1. OR Odds ratio, CI Confidence interval, HWE Hardy-Weinberg equilibrium
  2. pa: p values for individual genotypes in study group vs control; pb: p values for individual genotypes in sepsis subgroup vs septic shock subgroup; pc: p values for individual genotypes in septic shock subgroup vs control