Time to treatment for bacterial meningitis | 0 to 2 h | 2 to 6 h | > 6 h | |
---|---|---|---|---|
Data available for 74 of 84 patients | Hours (median and quartiles) | 23 of 74 (31%) | 16 of 74 (22%) | 35 of 74 (47%) |
1. CNS complications (n = 32) | 4.4 (1.3 to 22.4) | 11 of 23 (48%) | 6 of 16 (38%) | 15 of 35 (43%) |
Brain herniation (n = 7) | 1.0 (0.5 to 8.6) | 5 | 0 | 2 |
Brain infarct (n = 5) | 25.0 (5.2 to 52.5) | 1 | 0 | 4 |
Brain haemorrhage (n = 1) | 2.0 | 1 | 0 | 0 |
Intractable seizures (n = 6) | 11.0 (2.3 to 31.0) | 1 | 2 | 3 |
Global brain injury /unresponsive (n = 9) | 10.5 (3.3 to 34.8) | 1 | 2 | 6 |
CNS complications not further specified (n = 4) | 2.4 (1.3 to 4.5) | 2 | 2 | 0 |
2. Systemic complications (n = 28) | 5.3 (1.9 to 21.5) | 7 of 23 (30%) | 8 of 16 (50%) | 13 of 35 (37%) |
Circulatory failure /septic shock (n = 10) | 8.2 (1.0 to 40.8) | 3 | 1 | 6 |
Respiratory failure (n = 7) | 6.0 (3.5 to 20.0) | 1 | 3 | 3 |
Other organ failure (n = 2) | 9.5 (1.0 to 18.0) | 1 | 0 | 1 |
Systemic complications not futher specified (n = 9) | 3.9 (1.9 to 18.2) | 2 | 4 | 3 |
3. Combined CNS and systemic causes (n = 3) | 1.3 (0.6 to 4.5) | 2 of 23 (9%) | 1 of 16 (6%) | 0 of 35 (0%) |
4. Sudden unexpected death (n = 5) | 18.0 (1.9 to 39.0) | 1 of 23 (4%) | 1 of 16 (6%) | 3 of 35 (9%) |
5. Withdrawel of care (n = 4) | 4.2 (0.9 to 20.0) | 2 of 23 (9%) | 0 of 16 (0%) | 2 of 35 (6%) |
6. Unable to determine cause of death (n = 2) | 25.1 (24.0 to 26.3) | 0 of 23 (0%) | 0 of 16 (0%) | 2 of 35 (6%) |