Table 3 Prognosis, adequacy of antibiotic therapy, and surgical outcomes in MRSA versus MSSA IE
MSSA IE N = 378 | MRSA IE N = 59 | p* | |
|---|---|---|---|
Mortality at 1 year, n (%) | 165 (43.7) | 29 (49.1) | 0.32 |
Mortality at 1 year not related to IE, n (%) | 13 (4.2) | 0 | 0.316 |
Mortality attributable to SA IE in hospital or during the first 30 days post-discharge, n (%) | 152 (40.2) | 29 (49.1) | 0.222 |
Mortality attributable to IE in the following periods, n (%) | |||
1984–1999 | 35 (23) | 2 (6.99) | 0.122 |
2000–2009 | 64 (42.1) | 12 (41.4) | 0.215 |
2010–2017 | 52 (34.2) | 15 (51.7) | 0.062 |
Reinfection, n (%) | 6 (1.5) | 0 | 0.316 |
IE relapse, n (%) | 8 (3.1) | 4(6.8) | 0.053 |
Adequacy of antibiotic therapy, n (%) | 302/332 (91) | 40/46 (87) | 0.085 |
Days of antibiotic therapy, median (IQR) | 32 (19–44.5) | 41 (20–62) | 0.219 |
Hospital stay (days), median (IQR) | 30 (16–47) | 37 (21–58) | 0.019 |
Surgery not indicated n (%) | 128 (33.9) | 18 (30.5) | 0.189 |
Surgical treatment on admission, n (%) | 127 (32) | 15 (25.4) | 0.13 |
Postponed surgery after discharge, n (%) | 8 (2.1) | 0 | 0.61 |
Surgery indicated and conducted without delay, n (%) | 117 (30.9) | 12 (20.3) | 0.11 |
Surgery indicated and conducted with delay: > 72 h in left ventricular failure grade IV, n (%) | 9 (2.4) | 3 (5.1) | 0.21 |
Surgery indicated and not conducted in hospital, n (%) | 88 (23.3) | 18 (30.5) | 0.23 |
Surgery indicated but not conducted, n (%) | 38 (10.1) | 11 (18.6) | 0.052 |
Surgery indicated but not conducted due to poor clinical status, n (%) | 50 (13.2) | 7 (11.86) | 0.7 |