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Table 1 Main characteristics of premature neonates colonized or infected with Klebsiella pneumoniae during the outbreak in 2017

From: Successful control of an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae ST307 outbreak in a neonatal intensive care unit

Case

Sex

Interval*

Gestational age, (week + day)

Birth weight, (g)

Major invasive procedure

Type of infection

Positive culture specimens (date)

Exposure to RN 33d (date)

Empirical antibiotic regimen

Outcome (cause of death)

1b

M

5.4

24 + 0

640

CVC, MV

CLABSI

B (8/15)

NO

VA, TZP, MER

Cured

2

F

39.4

31 + 5

1505

CVC, MV

CLABSI

U (9/1), B (9/8)

NO

VA, MER, CC

Death (sepsis)

3c

M

48.4

24 + 0

640

CVC, MV, Explorative laparotomy

CLABSI

B (9/27)

NO

VA, TZP, MER

Death (sepsis)

4

M

5.0

29 + 5

1150

CVC, MV, Explorative laparotomy

Colonized

S (11/1)

Yes (11/17–12/18)

VA, TZP, MER

Cured

5

F

13.5

26 + 6

1042

CVC

NEC, BSI

B (12/6)

Yes (12/21)

VA, TZP, MER

Cured

6

F

41.4

26 + 1

790

CVC, MV, PDA ligation

CLABSI

B (12/10)

NO

VA, TZP, MER

Cured

7

F

21.9

27 + 2

1215

CVC

CLABSI

B (12/29)

NO

VA, TZP, MER

Death (sepsis)

  1. a Interval from birth till when detected positive for ESBL-KPN
  2. b Index case
  3. c Cases 1 and 3 are of the same neonate
  4. d RN (registered nurse) 33 was positive in the rectal swab culture
  5. CVC central venous catheter, MV mechanical ventilation, PDA patent ductus arteriosus, CLABSI central line-associated bloodstream infection, NEC necrotizing enterocolitis, B blood, U urine, S sputum, VA vancomycin, TZP piperacillin/tazobactam, MER meropenem, CC clindamycin