Table 1 Characteristics of MDR-TB patients in HCMC from 2011 to 2015
Characteristic | n (%) |
|---|---|
Total | 2266 |
Age at diagnosis (years, median (IQR)) | 43 (33–53) |
 > 60 years old | 197 (8.7%) |
 18–60 years old | 2037 (89.9%) |
 < 18 years old | 32 (1.4%) |
Male | 1715 (75.7%) |
Site of disease | |
 Pulmonary | 2237 (98.7%) |
 Multi-organ a | 37 (1.7%) |
 Extra pulmonary | 66 (3%) |
  Lymphadenitis | 22 |
  Meningitis | 21 |
  Pleuritis | 8 |
  Bone and vertebral | 4 |
  Soft tissue | 1 |
  Gastro-intestinal | 1 |
Registration group | |
 New | 128 (5.6%) |
 Relapse | 678 (29.9%) |
 Failure of regimen 1 | 512 (22.6%) |
 Failure of regiment 2 | 852 (37.6%) |
 Treatment after lost to follow-up | 47 (2.1%) |
 Transfer | 1 (0%) |
 Other | 46 (2%) |
 Not recorded | 2 (0.1%) |
Regimen of previous treatment | |
 I | 913 (40.3%) |
 II | 1012 (44.6%) |
 III | 2 (0.1%) |
 IV | 54 (2.4%) |
 No history of previous treatment | 128 (5.6%) |
 Unclear history | 157 (7%) |
BMI at diagnosis (kg/m2) | n = 1815 |
 Median (IQR) | 17.86 (15.76–19.96) |
 Overweight (BMI ≥ 25) | 46 (2.5%) |
 Normal BMI (BMI: 18.5- < 25) | 721 (39.7%) |
 Mild underweight (BMI: 17- < 18.5) | 343 (18.9%) |
 Moderate underweight (BMI: 16- < 17) | 250 (13.8%) |
 Severe underweight (BMI < 16) | 456 (25.1%) |
HIV positive | 204/2136 tested for HIV (9.6%) |
Diabetes | 359/1189 (30.2%) |
 Unknown history of diabetes | 1077 (47.5%) |
Initial Diagnosis Method | |
 DST | 274 (12.1%) |
 Xpert | 1276 (56.3%) |
 Hain | 705 (31.1%) |
 DST of last treatment episode | 7 (0.3%) |
 Missing data | 4 (0.2%) |
AFB smear at baseline | |
 Positive | 1748 (77.1%) |
   < 1+ | 158 (9%) |
  1+ | 895 (51.1%) |
  2+ | 357 (20.5%) |
  3+ | 275 (15.7%) |
  Unknown grade | 63 (3.7%) |
 Negative | 475 (21%) |
 Not recorded | 43 (1.9%) |
Culture at diagnosis | |
 Positive | 1371 (60.5%) |
 Negative | 178 (7.8%) |
 Non-Tuberculosis Mycobacterium (but Xpert positive)b | 4 (0.2%) |
 Contaminated | 19 (0.8%) |
 Not recorded | 694 (30.6%) |