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Table 1 Summary of mouse experiments

From: Pre-treatment with IL2 gene therapy alleviates Staphylococcus aureus arthritis in mice

ExperimentControlsTreatment regimenS. aureus strainBacterial dose (CFU/mouse)Mice
Infected miceHealthy miceNo treatmentLS-11 × 107NMRI
N = 44, one experiment
rAAV-IL2rAAV-LUC1010 vg at day −19 prior to bacterial inoculationLS-15 × 107C57BL/6
N = 60, two experiments
Adoptive transferPBS0.9 × 106 CD4+CD25+ cells at day −2 prior to bacterial inoculationLS-15 × 107C57BL/6
N = 12, one experiment
IL2 treatmentPBSDaily injections, starting at day 3 post bacterial inoculationLS-15 × 107C57BL/6
N = 18, two experiments
Anti-CD25 antibody treatmentRat IgG1 antibodyOne injection at day −3 prior bacterial inoculation and at day 3 post bacterial inoculation(1) LS-1
(2) Newman
(1) 3.5 × 107
(2) 6.5 × 106
(1) C57BL/6
N = 20, one experiment
(2) NMRI
N = 28, one experiment