Table 1 Summary of mouse experiments

Infected mice

Healthy mice

No treatment

LS-1

1 × 10⁷

NMRI

N = 44, one experiment

rAAV-IL2

rAAV-LUC

10¹⁰ vg at day −19 prior to bacterial inoculation

LS-1

5 × 10⁷

C57BL/6

N = 60, two experiments

Adoptive transfer

PBS

0.9 × 10⁶ CD4⁺CD25⁺ cells at day −2 prior to bacterial inoculation

LS-1

5 × 10⁷

C57BL/6

N = 12, one experiment

IL2 treatment

PBS

Daily injections, starting at day 3 post bacterial inoculation

LS-1

5 × 10⁷

C57BL/6

N = 18, two experiments

Anti-CD25 antibody treatment

Rat IgG1 antibody

One injection at day −3 prior bacterial inoculation and at day 3 post bacterial inoculation

(1) LS-1

(2) Newman

(1) 3.5 × 10⁷

(2) 6.5 × 10⁶

(1) C57BL/6

N = 20, one experiment

(2) NMRI

N = 28, one experiment