Fig. 5

Depletion of CD25⁺ Tregs. a, Experimental set-up for the depletion of Tregs using anti-CD25 antibodies and isotype control antibodies. b, Weight loss. c, Bacterial clearance in the kidneys. d, Clinical arthritis development. Depletion of CD25⁺ Tregs using anti-CD25 antibodies and isotype control antibodies in NMRI mice: e, Weight loss during the course of S. aureus arthritis. f, Bacterial clearance in the kidneys at day 10 after bacterial inoculation. g, Clinical arthritis development. In panels b, d, e and g, bars show the mean ± standard error of the mean (SEM). In panels c, and f, data are shown as median, whiskers = min to max. Statistical calculations were made using the Mann-Whitney U-test and one-way ANOVA, *P < 0.05