Table 1 Characteristics of the included studies
From: Serum 25-Hydroxyvitamin D and the risk of mortality in adult patients with Sepsis: a meta-analysis
Study | Design | Country | Diagnosis of Sepsis | Clinical setting | Sample size | Measured timing for 25 (OH) D | Measuring methods for 25 (OH) D | Mean age | Male | Cut-off for 25 (OH) D | Outcome data | Variables adjusted | NOS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Â | Â | Â | Â | years | % | pg/ml | Â | Â | Â |
Rech 2014 [20] | Retrospective | the US | SIRS | ICU | 121 | At admission | CLIA | 65.1 | 48.8 | < 15 | Mortality at 1 month | Age, African American race, APACHE II score, pulmonary source of sepsis, and any vitamin D supplementation | 6 |
Moromizato 2014 [19] | Retrospective | the US | SIRS | ICU | 568 | At admission | CLIA | 65.9 | 43.8 | < 30 | Mortality during hospitalization, at 1 month, at 3 months | Age, gender, race, type (surgical vs medical), and APACHE II score | 7 |
Ala-Kokko 2016 [21] | Prospective | Finland | SIRS | ICU | 610 | At admission | EIA | 62.4 | 63 | < 10, 10–20, 20–30 | Mortality at 3 months | APACHE II score, multiorgan failureduring 0–4 days, DM, use of systemic corticosteroids, LOH before ICU admission and AKI | 8 |
De Pascale 2016 [22] | Retrospective | the US | Sepsis-2.0 | ICU | 107 | At admission | CLIA | 65.7 | 57.9 | <  7 | Mortality at 12 months | Age, history of CKD, SAPS II, SOFA, and ARDS | 6 |
Trongtrakul 2017 [24] | Prospective | Thailand | Sepsis-2.0 | ED | 110 | At admission | CLIA | 57.9 | 49.1 | <  12, 12–20 | Mortality at 1 month | Age, sex and APACHE II score | 7 |
Ding 2017 [23] | Retrospective | China | Sepsis-2.0 | ICU | 57 | At admission | CLIA | 57.4 | 57.9 | < 20 | Mortality at 1 month | Age, sex, APACHE II score, and SOFA | 6 |
Suberviola 2019 [26] | Prospective | Spain | Sepsis-3.0 | ICU | 75 | At admission | CLIA | 64 | 70.7 | <  10 | Mortality during hospitalization | Age, sex, immunosuppression status, Charlson index, APACHE II score, and hepatic failure | 6 |
Mirijello 2019 [25] | Prospective | Italy | Sepsis-3.0 | ICU | 88 | At admission | NA | 75 | 57.9 | < 7 | Mortality at 1 month, and at 3 months | Age, sex, and MEDS score | 7 |