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Table 1 Characteristics of the included studies

From: Serum 25-Hydroxyvitamin D and the risk of mortality in adult patients with Sepsis: a meta-analysis

StudyDesignCountryDiagnosis of SepsisClinical settingSample sizeMeasured timing for 25 (OH) DMeasuring methods for 25 (OH) DMean ageMaleCut-off for 25 (OH) DOutcome dataVariables adjustedNOS
Rech 2014 [20]Retrospectivethe USSIRSICU121At admissionCLIA65.148.8< 15Mortality at 1 monthAge, African American race, APACHE II score, pulmonary source of sepsis, and any vitamin D supplementation6
Moromizato 2014 [19]Retrospectivethe USSIRSICU568At admissionCLIA65.943.8< 30Mortality during hospitalization, at 1 month, at 3 monthsAge, gender, race, type (surgical vs medical), and APACHE II score7
Ala-Kokko 2016 [21]ProspectiveFinlandSIRSICU610At admissionEIA62.463< 10, 10–20, 20–30Mortality at 3 monthsAPACHE II score, multiorgan failureduring 0–4 days, DM, use of systemic corticosteroids, LOH before ICU admission and AKI8
De Pascale 2016 [22]Retrospectivethe USSepsis-2.0ICU107At admissionCLIA65.757.9<  7Mortality at 12 monthsAge, history of CKD, SAPS II, SOFA, and ARDS6
Trongtrakul 2017 [24]ProspectiveThailandSepsis-2.0ED110At admissionCLIA57.949.1<  12, 12–20Mortality at 1 monthAge, sex and APACHE II score7
Ding 2017 [23]RetrospectiveChinaSepsis-2.0ICU57At admissionCLIA57.457.9< 20Mortality at 1 monthAge, sex, APACHE II score, and SOFA6
Suberviola 2019 [26]ProspectiveSpainSepsis-3.0ICU75At admissionCLIA6470.7<  10Mortality during hospitalizationAge, sex, immunosuppression status, Charlson index, APACHE II score, and hepatic failure6
Mirijello 2019 [25]ProspectiveItalySepsis-3.0ICU88At admissionNA7557.9< 7Mortality at 1 month, and at 3 monthsAge, sex, and MEDS score7
  1. ED Emergency department, ICU Intensive care unit, CLIA Chemiluminescence immunoassay; EIA Enzymatic immunoassay, NA Not available, APACHE II score Score on the Acute Physiology and Chronic Health Evaluation II, SAPS Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment, MEDS Mortality in the Emergency Department Sepsis, DM Diabetes mellitus, LOH Length of hospitalization, AKI Acute kidney injury, CKD Chronic kidney disease, ARDS Acute respiratory distress syndrome, SIRS Systemic inflammatory response syndrome