Emergence of human avian influenza A(H7N9) virus infections in Wenshan City in Southwest China, 2017

BMC Infectious Diseases

Table 1 Molecular characteristics of the H7N9 viruses isolated from humans in Wenshan 2017

Gene	Function	Mutation	Case No. Virus isolates
Gene	Function	Mutation	1A/Yunnan/32294/2017	2A/Yunnan/wenshan01/2017	3A/Yunnan/32291/2017	4A/Yunnan/32293/2017
HA	Increased binding to human type influenza receptor	G186V	V	V	V	V
	Increased binding to human type influenza receptor	Q226L	L	L	L	L
	Enhanced virulence in poultry		KGR↓G	KGR↓G	KGR↓G	KGR↓G
NA	Antiviral oseltamivir resistance	A246T	A	A	A	A
NA	Antiviral oseltamivir resistance	R292K	R	R	R	R
PB2	Increased virulence in mice	E627K	E	E	E	E
	Enhanced transmission in guinea pigs	D701N	D	D	D	D
	Species-specific signature positions	K702R	K	K	K	K
PB1	Increased transmission in Ferret	I368V	V	V	V	V
PA	Species-specific signature positions	V100A	V	V	V	V
	Increase the polymerase activity in mice	L336M	L	L	L	L
	Species specific signature positions	K356R	R	R	R	R
	Species specific signature positions	S409N	N	N	N	N
NS1	Altered virulence in mice	D92E	D	D	D	D
	altered antiviral response in host	N205S	S	S	S	S
	altered antiviral response in host	G210R	G	G	G	G
M	Anti-viral amantadine resistance	S31N	N	N	N	N

Notes: The HA residues are based on the H3 numbering system and the NA residues are based on the N2 numbering system. Other internal genes were numbered from the start codon
Abbreviations: HA hemagglutinin, NA neuraminidase, NS nonstructural protein, PA polymerase acidic protein, PB1 polymerase basic protein 1, PB2 polymerase basic protein 2, ↓ cleavage site

ISSN: 1471-2334