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Table 1 Molecular characteristics of the H7N9 viruses isolated from humans in Wenshan 2017

From: Emergence of human avian influenza A(H7N9) virus infections in Wenshan City in Southwest China, 2017

GeneFunctionMutationCase No.
Virus isolates
HAIncreased binding to human type influenza receptorG186VVVVV
Enhanced virulence in poultry KGR↓GKGR↓GKGR↓GKGR↓G
NAAntiviral oseltamivir resistanceA246TAAAA
PB2Increased virulence in miceE627KEEEE
Enhanced transmission in guinea pigsD701NDDDD
Species-specific signature positionsK702RKKKK
PB1Increased transmission in FerretI368VVVVV
PASpecies-specific signature positionsV100AVVVV
Increase the polymerase activity in miceL336MLLLL
Species specific signature positionsK356RRRRR
NS1Altered virulence in miceD92EDDDD
altered antiviral response in hostN205SSSSS
MAnti-viral amantadine resistanceS31NNNNN
  1. Notes: The HA residues are based on the H3 numbering system and the NA residues are based on the N2 numbering system. Other internal genes were numbered from the start codon
  2. Abbreviations: HA hemagglutinin, NA neuraminidase, NS nonstructural protein, PA polymerase acidic protein, PB1 polymerase basic protein 1, PB2 polymerase basic protein 2, ↓ cleavage site