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Table 2 Impact of positive microbiology on antimicrobial prescribing for different microbiological sampling types

From: The impact of diagnostic microbiology on de-escalation of antimicrobial therapy in hospitalised adults

Microbiology sample typePE with relevant positive microPositive micro result documented*Positive micro with ID/micro team involved*Positive micro where Abx were affected*Positive micro where Abx were de-escalated*
Blood1616 (100%)16 (100%)15 (94%)6 (38%)
Urine95 (56%)2 (22%)1 (11%)1 (11%)
Sputum75 (71%)4 (57%)2 (29%)0
CSF33 (100%)3 (100%)3 (100%)0
Total3529 (83%)25 (71%)21 (60%)7 (20%)
  1. Table shows the Prescription Episodes (PEs, defined in main text) with positive diagnostic microbiology broken down by microbiological sampling type (blood, urine, sputum, cerebrospinal fluid (CSF)). Compared with urine or sputum, positive blood and CSF cultures were more likely to be documented in the medical records, to have infectious diseases and/or microbiology teams involved, and to result in the antimicrobial regimen being altered (P<10-4 for pairwise comparisons between blood cultures and urine or sputum cultures, exact binomial test after Bonferroni correction for multiple comparisons). ID Infectious Diseases team, ABx Antimicrobials; * = Denominator for all cases is the “PE with relevant positive micro” column. Note that 33 PEs had significant positive microbiology; the total shown of 35 is because two patients had two positive culture types (blood and urine or blood and sputum) and these were counted separately for this table