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Table 2 Incidence rates (IR) of HPV-related anogenital warts, Anal LSIL and HSIL in men and Cervical LSIL and HSIL in women

From: Comorbidities associated with HPV infection among people living with HIV-1 in the southeastern US: a retrospective clinical cohort study

 

# Cases

# Total

Person-years

IR (95%CI)

P-Value

HPV-related Clinical Conditions (by gender)a

 Anogenital warts

478

4484

29,646.2

161.2 (146.8–175.7)

  Men

420

3429

22,286.2

188.5 (170.4–206.5)

< 0.0001

Women

51

1038

7507.9

67.9 (49.3–86.6)

 Anal LSIL

425

4484

21,854.0

194.5 (176.0–213.0)

  Men

411

3429

21,842.3

188.2 (170.0–206.4)

< 0.0001

  Women

8

1031

5436.6

14.7 (12.1–24.9)

 Anal HSIL

75

4484

22,195.0

33.8 (26.1–41.4)

  Men

72

3429

16,665.5

43.2 (33.2–53.2)

< 0.0005

  Women

3

1031

5434.8

5.5 (0–11.8)

 Anal cancer

43

4484

22,188.2

19.4 (13.6–25.2)

  Men

43

3429

16,680.7

25.8 (18.1–33.5)

< 0.0001

  Women

0

1031

5416.0

0

 Bowen’s disease

6

4484

22,232.1

2.7 (0.55–4.9)

  Men

5

3429

16,701.2

3.0 (0.37–5.7)

0.66

  Women

1

1031

5436.3

1.8 (0–5.6)

HPV-related Clinical Conditions (by race)a

 Anogenital warts

478

4484

29,646.2

161.2 (146.8–175.7)

  Black

312

2676

18,360.7

169.9 (151.1–188.8)

0.32

  White

160

1632

10,382.2

154.1 (130.2–178.0)

 Anal LSIL

425

4484

21,854.0

194.5 (176.0–213.0)

  Black

182

2676

12,892.1

141.2 (120.7–161.7)

< 0.0001

  White

238

1632

8447.4

281.7 (207.8–317.5)

 Anal HSIL

75

4484

22,195.0

33.8 (26.1–41.4)

  Black

40

2676

13,053.3

30.6 (21.1–40.1)

0.28

  White

34

1632

8628.5

39.4 (26.5–53.3)

 Anal cancer

43

4484

22,188.2

19.4 (13.6–25.2)

  Black

18

2716

13,030.0

13.8 (7.4–20.2)

0.025

  White

24

1632

8643.7

27.8 (16.7–38.9)

 Cervical LSIL

171

1031

7352.3

232.6 (197.7–267.4)

  Black

132

767

5679.6

232.4 (192.8–272.0)

0.69

  White

38

236

1610.2

250.3 (102.1–290.9)

 Cervical HSIL

80

1031

7404.7

108.0 (84.5–131.7)

  Black

54

767

5721.3

94.4 (69.2–119.6)

0.023

  White

25

236

1529.5

163.5 (99.4–169.6)

 Cervical cancer

12

1031

5304.8

22.62 (9.8–35.4)

  Black

6

767

4018.1

14.9 (3.0–26.9)

0.037

  White

6

235

1203.4

49.9 (3.0–38.9)

 Vaginal/Vulvar cancer

15

1031

5304.3

28.3 (14.0–42.6)

  Black

11

767

4018.1

27.4 (11.2–43.6)

0.74

  White

4

236

1202.9

33.3 (0.67–65.8)

 Penile cancer

4

3429

16,493.2

2.3 (0.049–4.8)

 

  Black

3

886

8769.5

3.4 (0–7.3)

< 0.0001

  White

0

1396

7298.4

0

 Bowen’s disease

6

4484

22,232.1

2.7 (0.55–4.9)

  Black

3

2676

13,070.1

2.3 (0–4,9)

0.61

  White

3

1632

8647.5

3.5 (0–7.4)

  1. a: Comparisons were only conducted between men vs. women and blacks vs. whites because very few transgender and other race individuals presented in the study