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Table 1 Increase of mutation types and rates associated with failure of first-line treatment for HIV-1 CRF01_AE

From: Natural polymorphisms in HIV-1 CRF01_AE strain and profile of acquired drug resistance mutations in a long-term combination treatment cohort in northeastern China

Site of RT

B-WT

 

Mutation rate (%)

Increase (%)

Binomial distribution

McNemar test

Mutations

Baseline

TF

Z value

p

p

62

A

V

0

14.3

14.3

2.542

< 0.05

0.031

65

K

R

0

57.1

57.1

5.797

< 0.05

< 0.001

68

S

G

4.8

26.2

21.4

2.715

< 0.05

0.004

70

K

E, R

0

9.5

9.5

2.049

< 0.05

0.125

75

V

L, I, A

4.8

23.8

19.0

2.494

< 0.05

0.008

101

K

E, Q, N

0

52.4

52.4

5.460

< 0.05

< 0.001

103

K

R, N, S

21.4

42.9

21.5

2.103

< 0.05

0.004

106

V

M

2.4

23.8

21.4

2.911

< 0.05

0.012

115

Y

F

0

9.5

9.5

2.049

< 0.05

0.125

179

V

D, I, A, T, E

26.2

45.2

19.0

1.822

> 0.05

0.008

181

Y

C

0

42.9

42.9

4.786

< 0.05

< 0.001

184

M

V, I

0

47.6

47.6

5.123

< 0.05

< 0.001

190

G

S, C

0

66.7

66.7

6.481

< 0.05

< 0.001

228

L

R

0

11.9

11.9

2.306

< 0.05

0.063

  1. B-WT subtype B wild type, TF treatment failure. Boldface P values indicate P < 0.05. The boldface sites are known drug resistance-associated sites. The mutations listed are the types of mutations that occur at TF time point