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Fig. 2 | BMC Infectious Diseases

Fig. 2

From: Different macrophage polarization between drug-susceptible and multidrug-resistant pulmonary tuberculosis

Fig. 2

The M1-like and M2-like polarization rates between the DS-TB and MDR-TB/XDR-TB groups. a The M1-like polarization rate did not differ significantly between the two groups, while the M2-like polarization rate was significantly higher in the MDR-TB/XDR-TB group than in the DS-TB group. b The ratio of the M2-like polarization rate to the M1-like polarization rate (macrophage polarization ratio (MP ratio) = M2-like polarization rate / M1-like polarization rate) was calculated, and the natural logarithm of the ratio [Ln (MP ratio)] was compared between the two groups. The Ln (MP ratio) was significantly higher in the MDR-TB/XDR-TB group than in the DS-TB group. c The M1 polarization rate was dichotomized into the low M1 group and high M1 group based on the median value, and the differences in the M2-like polarization rate between the DS-TB and MDR-TB/XDR-TB groups were analyzed in each M1 group. The M2-like polarization rate of the MDR-TB/XDR-TB group was significantly higher than that of the DS-TB group within the low M1 group, but the M2-like polarization rate was not significantly different between the two groups within the high M1 group. Statistical comparisons between the DS-TB and MDR-TB/XDR-TB groups were performed using Student’s t-test (*) and the Mann-Whitney U test (). DS = dru-susceptible tuberculosis; DR = drug-resistant tuberculosis (MDR-TB/XDR-TB); MDR-TB = multidrug-resistant tuberculosis; XDR-TB = extensively drug-resistant tuberculosis; Arg1 = Arginase-1

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