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Table 4 Associations between Tuberculosis Contact Score, the Infectivity Score and other risk factors for tuberculosis (TB) and the dependent variables TST1 and QFT1 in 525 household contacts of 161 adults with pulmonary TB

From: Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations

 Subclinical TB vs other HHCs
univariatemultivariate2multivariate3
OR (95% CI)OR (95% CI)OR (95% CI)
Tuberculosis Contact Score1.07 (0.90, 1.27)0.98 (0.76, 1.27) 
InfectivityScore1.31 (0.96, 1.80) 1.35 (0.87, 2.12)
Gender0.71 (0.34, 1.52)0.78 (0.32, 1.85)0.75 (0.32, 1.81)
Age (years)4
  < 51.05 (0.23, 4.80)2.14 (0.37, 12.3)2.39 (0.42, 13.7)
 5–141.80 (0.82, 3.96)2.63 (0.87, 7.96)2.71 (0.88, 8.33)
  > 14refrefref
 BCG scar present1.11 (0.50, 2.45)1.01 (0.41, 2.50)0.99 (0.40, 2.44)
Individual risk factors
 Diabetes mellitus1.96 (0.24, 16.2)1.53 (0.17, 14.0)1.73 (0.19, 16.2)
 Smoking1.17 (0.50, 2.71)1.61 (0.49, 5.27)1.63 (0.49, 5.38)
  ≥ 1 individual risk factors1.11 (0.48, 2.58)  
 BMI50.89 (0.73, 1.09)0.92 (0.73, 1.16)0.92 (0.73, 1.16)
 BMIZ51.00 (0.73, 1.38)0.87 (0.61, 1.24)0.82 (0.56, 1.19)
Environmental risk factors
 Crowding60.79 (0.62, 0.99)0.72 (0.54, 0.95)0.71 (0.53, 0.95)
In-door pollution7
 LPG0.53 (0.12, 2.31)0.45 (0.10, 2.08)0.38 (0.08, 1.78)
 Kerosene1.15 (0.14, 9.22)00
 Wood + agri residuerefrefref
  1. 1Tuberculin Skin Test (TST) was dichotomized around the cutoff 10 mm; ≥10 mm corresponding to TST+ and < 10 mm corresponding to TST-. Quantiferon (QFT) was dichotomized around the cutoff 0.35 IU/mL; ≥0.35 IU/mL corresponding to QFT+ and < 0.35 IU/mL corresponding to QFT- (Subjects with indeterminate QFT is excluded from analysis). 2Analysis including the TCS. 3Analysis including the Infectivity Score. 4WHO based age categories. 5Since assessments of body weight is different in 5asubjects aged ≥15 years (Body Mass Index, BMI) and 5b < 15 years (Body Mass Index Z-score, BMIZ), BMI and BMIZ were only entered in the models evaluating this variable, which were then done stratified for age. 6Number of household members divided on rooms in the house
  2. ORs in bold are significantly different from 1 (p<0.05)