Skip to main content

Table 4 Associations between Tuberculosis Contact Score, the Infectivity Score and other risk factors for tuberculosis (TB) and the dependent variables TST1 and QFT1 in 525 household contacts of 161 adults with pulmonary TB

From: Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations

  Subclinical TB vs other HHCs
univariate multivariate2 multivariate3
OR (95% CI) OR (95% CI) OR (95% CI)
Tuberculosis Contact Score 1.07 (0.90, 1.27) 0.98 (0.76, 1.27)  
InfectivityScore 1.31 (0.96, 1.80)   1.35 (0.87, 2.12)
Gender 0.71 (0.34, 1.52) 0.78 (0.32, 1.85) 0.75 (0.32, 1.81)
Age (years)4
  < 5 1.05 (0.23, 4.80) 2.14 (0.37, 12.3) 2.39 (0.42, 13.7)
 5–14 1.80 (0.82, 3.96) 2.63 (0.87, 7.96) 2.71 (0.88, 8.33)
  > 14 ref ref ref
 BCG scar present 1.11 (0.50, 2.45) 1.01 (0.41, 2.50) 0.99 (0.40, 2.44)
Individual risk factors
 Diabetes mellitus 1.96 (0.24, 16.2) 1.53 (0.17, 14.0) 1.73 (0.19, 16.2)
 Smoking 1.17 (0.50, 2.71) 1.61 (0.49, 5.27) 1.63 (0.49, 5.38)
  ≥ 1 individual risk factors 1.11 (0.48, 2.58)   
 BMI5 0.89 (0.73, 1.09) 0.92 (0.73, 1.16) 0.92 (0.73, 1.16)
 BMIZ5 1.00 (0.73, 1.38) 0.87 (0.61, 1.24) 0.82 (0.56, 1.19)
Environmental risk factors
 Crowding6 0.79 (0.62, 0.99) 0.72 (0.54, 0.95) 0.71 (0.53, 0.95)
In-door pollution7
 LPG 0.53 (0.12, 2.31) 0.45 (0.10, 2.08) 0.38 (0.08, 1.78)
 Kerosene 1.15 (0.14, 9.22) 0 0
 Wood + agri residue ref ref ref
  1. 1Tuberculin Skin Test (TST) was dichotomized around the cutoff 10 mm; ≥10 mm corresponding to TST+ and < 10 mm corresponding to TST-. Quantiferon (QFT) was dichotomized around the cutoff 0.35 IU/mL; ≥0.35 IU/mL corresponding to QFT+ and < 0.35 IU/mL corresponding to QFT- (Subjects with indeterminate QFT is excluded from analysis). 2Analysis including the TCS. 3Analysis including the Infectivity Score. 4WHO based age categories. 5Since assessments of body weight is different in 5asubjects aged ≥15 years (Body Mass Index, BMI) and 5b < 15 years (Body Mass Index Z-score, BMIZ), BMI and BMIZ were only entered in the models evaluating this variable, which were then done stratified for age. 6Number of household members divided on rooms in the house
  2. ORs in bold are significantly different from 1 (p<0.05)