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Table 3 Associations between Tuberculosis Contact Score, the Infectivity Score and other risk factors for tuberculosis (TB) and the dependant variables TST1 and QFT1 in 525 household contacts of 161 adults with pulmonary TB

From: Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations

 

TST- vs TST + 1

QFT- vs QFT + 1

univariate

multivariate2

multivariate3

univariate

multivariate2

multivariate3

OR (95%CI)

OR (95%CI)

OR (95%CI)

OR (95%CI)

OR (95%CI)

OR (95%CI)

Tuberculosis Contact Score

1.15 (1.05, 1.26)

1.16 (1.01, 1.33)

 

1.22 (1.12, 1.32)

1.33 (1.16, 1.51)

 

InfectivityScore

1.28 (1.11, 1.48)

 

1.39 (1.10, 1.76)

1.25 (1.11, 1.42)

 

1.41 (1.16, 1.71)

Gender

1.44 (0.97, 2.13)

1.35 (0.85, 2.15)

1.37 (0.87, 2.18)

1.38 (0.95, 1.99)

1.38 (0.88, 2.16)

1.47 (0.94, 2.28)

Age (years)4

  < 5

0.44 (0.19, 1.02)

0.71 (0.27, 1.87)

0.72 (0.28, 1.88)

0.46 (0.23, 0.91)

0.87 (0.36, 2.11)

0.81 (0.34, 1.92)

 5–14

1.07 (0.70, 1.62)

1.05 (0.61, 1.82)

1.05 (0.61, 1.82)

1.20 (0.79, 1.81)

1.27 (0.74, 2.17)

1.32 (0.77, 2.24)

  > 14

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 BCG scar present

0.93 (0.62, 1.38)

1.04 (0.65, 1.65)

1.02 (0.64, 1.63)

0.66 (0.45, 0.97)

0.64 (0.40, 1.01)

0.63 (0.40, 1,00)

Individual risk factors

 Diabetes mellitus

0.26 (0.03, 2.09)

0.22 (0.03, 1.83)

0.22 (0.03, 1.84)

2.80 (0.58, 13.61)

3.41 (0.62, 18.69)

3.26 (0.60, 17.79)

 Smoking

1.21 (0.78, 1.86)

1.64 (0.93, 2.89)

1.67 (0.94, 2.96)

1.18 (0.77, 1,79)

1.15 (0.65, 2.04)

1.15 (0.65, 2.03)

  ≥ 1 individual risk factors

1.19 (0.77, 1.82)

  

1.21 (0.80, 1.84)

  

 BMI5a

0.98 (0.90, 1.05)

0.96 (0.86, 1.06)

0.96 (0.88, 1.06)

1.03 (0.96, 1.11)

0.97 (0.88, 1.06)

0.99 (0.90, 1.08)

 BMIZ5b

1.03 (0.86, 1.24)

na

na

1.16 (0.97, 1.38)

na

na

Environmental risk factors

 Crowding6

1.01 (0.91, 1.11)

1.09 (0.97, 1.22)

1.09 (0.97, 1.22)

0.92 (0.84, 1.01)

0.99 (0.88, 1.11)

0.97 (0.87, 1.08)

In-door pollution7

 LPG

1.78 (1.01, 3.15)

2.05 (1.07, 3.93)

1.96 (1.02, 3.76)

1.48 (0.81, 2.68)

1.28 (0.65, 2.54)

1.25 (0.63, 2.47)

 Kerosene

1.89 (0.62, 5.76)

2.17 (0.67, 7.08)

2.34 (0.72, 7.59)

1.80 (0.55, 5.96)

1.15 (0.33, 4.09)

1.37 (0.39, 4.83)

 Wood + agri residue

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  1. 1Tuberculin Skin Test (TST) was dichotomized around the cutoff 10 mm; ≥10 mm corresponding to TST+ and < 10 mm corresponding to TST-. Quantiferon (QFT) was dichotomized around the cutoff 0.35 IU/mL; ≥0.35 IU/mL corresponding to QFT+ and < 0.35 IU/mL corresponding to QFT- (Subjects with indeterminate QFT is excluded from analysis). 2Analysis including the TCS; 3Analysis including the Infectivity Score. 4WHO based age categories. 5Since assessments of body weight is different in 5asubjects aged ≥15 years (Body Mass Index, BMI) and 5b < 15 years (Body Mass Index Z-score, BMIZ), BMI and BMIZ were only entered in the models evaluating this variable, which were then done stratified for age. 6Number of household members divided on rooms in the house. 7Grading based on type of fuel, (Wood + agricultural residue) = 3, Kerosene = 2, LPG = 1
  2. ORs in bold are significantly different from 1 (p<0.05)