Cryptococcal antigenemia is associated with meningitis or death in HIV-infected adults with CD4 100–200 cells/mm3

BMC Infectious Diseases

Table 2 Incidence of cryptococcal meningitis or death within 14 months of enrollment by laboratory-based EIA testing among participants with low CD4 count at enrollment

				Incidence Rate¹	Unadjusted
CD4 count at enrollment	N	Events (n)	py	Incidence Rate¹	HR (CI)	p=
100–200 cells/mm³
CrAg positive	4	2	3.4	58.8	10.0 (2.2, 45.3)	0.003
CrAg negative or indeterminate	205	11	196.2	5.6	Ref
<100 cells/mm³
CrAg positive	10	7	5.1	137.6	6.3 (2.7, 14.6)	< 0.001
CrAg negative or indeterminate	169	26	145.8	17.8	Ref

CI 95% confidence interval, CrAg Cryptococcus antigen, EIA enzyme immunoassay, HR Hazard ratio, py person-years
¹# of total outcomes per 100 person-years

ISSN: 1471-2334