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Table 3 Unconditional logistic multiple regression model of risk factors for IRIS-TB among HIV-TB individuals

From: Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes

Features Level Patients without IRIS (N = 77) Patients with IRIS (N = 11) Adjusted Model
aORa 95%CI P-valueb
CD8 (>500) 47 (68.12) 3 (30) Ref
(≤500) 22 (31.88) 7 (70) 18.23 1.71–193.79 0.016
HLA-B*41 not carriers 75 (97.4) 10 (90.91) Ref
carriers 2 (2.6) 1 (9.09) 68.84 1.41–3369.9 0.033
KIR2DS2 not carriers 40 (51.95) 2 (18.18) Ref
carriers 37 (48.05) 9 (81.82) 27.22 1.33–558.6 0.032
KIR2DS1 + C2 not carriers 69 (89.61) 8 (72.73) Ref
carriers 8 (10.39) 3 (27.27) 28.58 1.54–530.65 0.024
KIR2DL3 + C1/C2 not carriers 37 (49.33) 9 (81.82) 43.04 1.32–1404.01 0.034
carriers 38 (50.67) 2 (18.18) Ref
KIR2DL1 + C1/C2 not carriers 37 (49.33) 9 (81.82) 43.04 1.32–1404.01 0.034
carriers 38 (50.67) 2 (18.18) Ref
  1. N number of individuals in each group, OR odds ratio, aOR adjusted odds ratio, 95% CI 95% confidence interval, REF Reference, HLA human leukocyte antigen, IRIS immune reconstitution inflammatory syndrome
  2. aOdds ratios were adjusted by skin color, education, site of tuberculosis, and CD8 count when appropriate. bP-values were calculated using the unconditional logistic regression model. Differences were considered significant with a value of * P < 0.05