Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes

Table 3 Unconditional logistic multiple regression model of risk factors for IRIS-TB among HIV-TB individuals

Features	Level	Patients without IRIS (N = 77)	Patients with IRIS (N = 11)	Adjusted Model
Features	Level	Patients without IRIS (N = 77)	Patients with IRIS (N = 11)	aOR^a	95%CI	P-value^b
CD8	(>500)	47 (68.12)	3 (30)	Ref
CD8	(≤500)	22 (31.88)	7 (70)	18.23	1.71–193.79	0.016
HLA-B*41	not carriers	75 (97.4)	10 (90.91)	Ref
HLA-B*41	carriers	2 (2.6)	1 (9.09)	68.84	1.41–3369.9	0.033
KIR2DS2	not carriers	40 (51.95)	2 (18.18)	Ref
KIR2DS2	carriers	37 (48.05)	9 (81.82)	27.22	1.33–558.6	0.032
KIR2DS1 + C2	not carriers	69 (89.61)	8 (72.73)	Ref
KIR2DS1 + C2	carriers	8 (10.39)	3 (27.27)	28.58	1.54–530.65	0.024
KIR2DL3 + C1/C2	not carriers	37 (49.33)	9 (81.82)	43.04	1.32–1404.01	0.034
KIR2DL3 + C1/C2	carriers	38 (50.67)	2 (18.18)	Ref
KIR2DL1 + C1/C2	not carriers	37 (49.33)	9 (81.82)	43.04	1.32–1404.01	0.034
KIR2DL1 + C1/C2	carriers	38 (50.67)	2 (18.18)	Ref

N number of individuals in each group, OR odds ratio, aOR adjusted odds ratio, 95% CI 95% confidence interval, REF Reference, HLA human leukocyte antigen, IRIS immune reconstitution inflammatory syndrome
^aOdds ratios were adjusted by skin color, education, site of tuberculosis, and CD8 count when appropriate. ^bP-values were calculated using the unconditional logistic regression model. Differences were considered significant with a value of ^* P < 0.05

ISSN: 1471-2334