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Table 3 Unconditional logistic multiple regression model of risk factors for IRIS-TB among HIV-TB individuals

From: Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes

FeaturesLevelPatients without IRIS (N = 77)Patients with IRIS (N = 11)Adjusted Model
aORa95%CIP-valueb
CD8(>500)47 (68.12)3 (30)Ref
(≤500)22 (31.88)7 (70)18.231.71–193.790.016
HLA-B*41not carriers75 (97.4)10 (90.91)Ref
carriers2 (2.6)1 (9.09)68.841.41–3369.90.033
KIR2DS2not carriers40 (51.95)2 (18.18)Ref
carriers37 (48.05)9 (81.82)27.221.33–558.60.032
KIR2DS1 + C2not carriers69 (89.61)8 (72.73)Ref
carriers8 (10.39)3 (27.27)28.581.54–530.650.024
KIR2DL3 + C1/C2not carriers37 (49.33)9 (81.82)43.041.32–1404.010.034
carriers38 (50.67)2 (18.18)Ref
KIR2DL1 + C1/C2not carriers37 (49.33)9 (81.82)43.041.32–1404.010.034
carriers38 (50.67)2 (18.18)Ref
  1. N number of individuals in each group, OR odds ratio, aOR adjusted odds ratio, 95% CI 95% confidence interval, REF Reference, HLA human leukocyte antigen, IRIS immune reconstitution inflammatory syndrome
  2. aOdds ratios were adjusted by skin color, education, site of tuberculosis, and CD8 count when appropriate. bP-values were calculated using the unconditional logistic regression model. Differences were considered significant with a value of * P < 0.05