Hepatitis B testing, treatment, and virologic suppression in HIV-infected patients in Cameroon (ANRS 12288 EVOLCAM)

Table 3 Factors associated with HBV suppression in HIV/HBV coinfected patients using multilevel logistic regressions

	HBV viral load < 10 IU/mL		Univariate analysis			Multivariate analysis
	n	(%)	OR	95% CI	p	Adjusted OR	95% CI	p
School educational level
Lower than secondary	34	(63.0%)	1.00			1.00
Secondary or higher	80	(77.7%)	2.04	0.97–4.27	0.058	2.31	1.05–5.07	0.037
CD4 cell count (per 100 cells/mm³ increase)			1.19	1.01–1.41	0.033
HIV viral load (copies/mL)
≥ 300	20	(54.1%)	1.00			1.00
< 300	94	(78.3%)	3.26	1.42–7.46	0.005	3.46	1.48–8.09	0.004
ALT level (per 10 IU/L increase)			0.91	0.81–1.02	0.111	0.86	0.75–0.97	0.019
AST level (per 10 IU/L increase)			0.86	0.75–0.99	0.033
Time since ART initiation (per 5-year increase)			2.44	1.11–5.34	0.025
Duration of 3TC/FTC monotherapy (per 1-year increase)			1.18	1.01–1.36	0.042
Adherence to ART in the previous 4 weeks
Perfect adherence	26	(59.9%)	1.00
Adherence difficulties^a	60	(76.9%)	2.40	1.04–5.52	0.039
Treatment interruption more than 2 consecutive days	28	(80.0%)	2.83	0.97–8.21	0.055
Region of study hospital
Centre	74	(76.3%)	1.00
Littoral	40	(66.7%)	0.58	0.25–1.35	0.206	0.42	0.19–0.96	0.039
Type of HIV service
Primary	55	(64.7%)	1.00			1.00
Secondary	59	(81.9%)	2.47	1.17–5.22	0.017	2.79	1.24–6.27	0.013

Abbreviations: ART antiretroviral therapy, CI confidence interval, OR odds ratio, ALT Alanine aminotransferase, AST Aspartate aminotransferase
^a Missed prescribed drug doses or not fully respecting the prescription schedule
The following characteristics were not associated with HBV suppression: gender; age; residence setting; marital status; paid activity; household monthly income; living below poverty line; number of meals per day; body mass index; anti-HBV drugs as part of ART; duration of current ART; hospitalization in the previous 3 months; consultation of a traditional healer in the previous 3 months; journey time to arrive at study hospital; setting and administrative sector of study hospital; task-shifting of ART prescription renewals or follow-up consultations to nurses; stock-out of ART in the previous 12 months

ISSN: 1471-2334