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Table 1 PK/PD targets and thresholds for dose reduction of antibiotic groups

From: The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial

Antimicrobials Target Threshold dose reduction
Beta-lactams fT above MIC = 100% Ctrough > 10 x MIC
Ciprofloxacin fAUC0-24h/MIC ratio ≥> 100  fAUC0-24h/MIC ratio > 400