From: The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial
Antimicrobials
Target
Threshold dose reduction
Beta-lactams
fT above MIC = 100%
Ctrough > 10 x MIC
Ciprofloxacin
fAUC0-24h/MIC ratio ≥> 100 
fAUC0-24h/MIC ratio > 400