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Table 1 PK/PD targets and thresholds for dose reduction of antibiotic groups

From: The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial

AntimicrobialsTargetThreshold dose reduction
Beta-lactamsfT above MIC = 100%Ctrough > 10 x MIC
CiprofloxacinfAUC0-24h/MIC ratio ≥> 100 fAUC0-24h/MIC ratio > 400