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Table 1 Summary of serum and cerebrospinal fluid investigations

From: Case report: meningitis as a presenting feature of anti-NMDA receptor encephalitis

SERUMCEREBROSPINAL FLUID
(Three lumbar punctures performed on admission days 1, 13 & 23) (reference range)
InfectiveAutoimmuneTumour markers
(reference range)
Admission day11323
Negative for:
HIV antigen/antibody
Hepatitis C antibody
Anti-treponemal IgG
CMV IgM and IgG
EBV IgM
Leptospirosis IgM
Borrelia antibody
Cryptococcal antigen
Blood cultures
Negative for:
Anti-VGKC
MPO & PR3-ANCA
C3 and C4
ANA
Anti-CCP
Anti-Ro
Anti-La
Anti-Smith
Anti-RNP
Anti-Scl-70
Anti-Jo
LDH: 265 (125–220 units/liter)
CA-125: 8 (0–35 units/mL)
β-HCG: < 1 (< 5 m-international units/mL)
AFP: < 2 (< 6 ng/mL)
No paraproteins
Normal immunoglobulin levels.
Opening pressure (cm H20) (5–20)3217Not available
White cell count (× 106/L) (< 5)172 (100% lymphocytes)85 (Differential not available)143 (100% lymphocytes)
Red cell count (×106/L) (0)3560
Protein (g/L) (0.15–0.60)0.771.070.32
Glucose(serum glucose) (g/L) (60–80% of serum)2.3 (no serum)2.5 (10·5)3.8 (6·1)
Cryptococcal antigenNegative
ANCANegative
MicroscopyNo organisms seen (all three samples)
Microbiology (by PCR)Negative for:
Bacteria: H. influenza, S. pneumoniae, N. meningitidis (all samples)
Virus: enterovirus, HSV 1 & 2, VZV, parechovirus (all samples)
Culture and sensitivityNo growth, No mycobacteria (all samples)
CytologyNo malignant cells detected (all samples)
  1. HIV Human Immunodeficiency Virus, CMV Cytomegalovirus, EBV Epstein - Barr virus, PCR Polymerase Chain Reaction, Anti-VGKC Anti-voltage gated potassium channel, MPO & PR3 ANCA Myeloperoxidase and proteinase-3 anti-neutrophil cytoplasmic antibody, C3 and C4 Complement component 3 and 4, ANA Anti-nuclear antibody, Anti-CCP Anti-cyclic citrullinated peptide, Anti-RNP Anti-ribonucleoprotein, Anti-Scl 70 Anti-scleroderma, also known as anti-topoisomerase 1, Anti-Jo-1 Antibodies to histidyl tRNA synthetase, LDH Lactate dehydrogenase, CA-125 Cancer antigen-125, β-HCG Beta human chorionic gonadotropin, AFP Alpha-fetoprotein, ANCA Anti-neutrophil cytoplasmic antigen, H. influenzae Haemophilus influenzae, S. pneumonia Streptococcus pneumoniae, N. meningitidis Neisseria meningitidis, HSV Human simplex virus, VZV Varicella zoster virus