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Table 3 Univariable and multivariable analysis of risk factors for genotypic pyrazinamide resistance (pncA mutation)

From: Value of pyrazinamide for composition of new treatment regimens for multidrug-resistant Mycobacterium tuberculosis in China

Characteristic

All cases

n (%)

Wild type in pncA gene

n (%)

Mutation in pncA gene

n (%)

Crude

Prevalence ratio (95%CI)

Adjusted

Prevalence ratio (95%CI)

P value

Gender

 Male

211 (65.1)

136 (66.7)

75 (62.5)

1.0

1.0

 

 Female

113 (34.9)

68 (33.3)

45 (37.5)

1.12 (0.84–1.50)

11 (0.82–1.46)

0.56

Age (years)

 <40

153 (47.2)

87 (42.6)

66 (55.0)

1.0

1.0

 

 40–59

108 (33.3)

69 (33.8)

39 (32.5)

0.84 (0.61–1.14)

0.82 (0.60–1.11)

0.20

60

63 (19.4)

48 (23.5)

15 (12.5)

0.55 (0.34–0.89)

0.56 (0.34–0.91)

0.02

Residence in area within China

 East of china

104 (32.1)

69 (33.8)

35 (29.2)

1.0

NA

 

 Central of china

162 (50.0)

96 (47.1)

66 (55.0)

1.21 (0.87–1.68)

NA

 

 West of china

58 (17.9)

39 (19.1)

19 (15.8)

0.97 (0.61–1.54)

NA

 

Occupationv

 Farmer

202 (62.3)

135 (66.2)

67 (55.8)

1.0

NA

 

 Others

122 (37.7)

69 (33.8)

53 (44.2)

1.31 (0.99–1.74)

NA

 

Residence in area according to start DOTS implementation

 In 2000 or later

187 (57.7)

112 (54.9)

75 (62.5)

1.0

NA

 

 Before 2000

137 (42.3)

92 (45.1)

45 (37.5)

0.82 (0.61–1.10)

NA

 

Number of previous treatments

 0

132 (40.7)

88 (43.1)

44 (36.7)

1.0

  

 1

107 (33.0)

67 (32.8)

40 (33.3)

1.12 (0.80–1.58)

1.17 (0.84–1.63)

0.35

 More than 1

81 (25.0)

47 (23.0)

34 (28.3)

1.26 (0.89–1.79)

1.55 (0.90–1.84)

0.18

 Unknown

4 (1.2)

2 (1.0)

2 (1.7)

1.50 (0.55–4.12)

2.56 (1.72–3.82)

< 0.001

Previous pyrazinamide usage

 Yes

144 (44.4)

93 (45.6)

51 (42.5)

1.0

NA

 

 No

180 (55.6)

111 (54.4)

69 (57.5)

1.08 (0.81–1.44)

NA

 

Genotype

 Non-beijing strain

42 (13.0)

32 (15.7)

10 (8.3)

1.0

1.0

 

 Beijing strain

230 (71.0)

139 (68.1)

91 (75.8)

1.66 (0.95–2.92)

1.84 (1.01–3.34)

0.045

 No data

52 (16.0)

33 (16.2)

19 (15.8)

1.54 (0.80–2.94)

1.64 (0.82–3.25)

0.16

  1. Note: NA not applicable, these variables were not included in the final mode