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Fig. 2 | BMC Infectious Diseases

Fig. 2

From: Severe Candida glabrata pancolitis and fatal Aspergillus fumigatus pulmonary infection in the setting of bone marrow aplasia after CD19-directed CAR T-cell therapy – a case report

Fig. 2

Radiographic evidence of partial response to Axi-cel after 36 days. Contrast-enhanced CT abdomen (axial view) displaying pleural manifestations before (a) and after (b) CAR T-cell treatment. Involved paraaortic lymph nodes (red arrows) demonstrate an interval decrease in size (c-d, e-f). The inset of panel F depicts splenic hypodensities consistent with necrosis of tumor tissue secondary to immune therapy and a reduction of splenomegaly. G Graphical depiction of response over time. Tumor extent was quantified as the sum of the product of perpendicular diameters according to Lugano criteria over 3 time points and is graphed on the y-axis. H Timeline of LDH levels (U/l). The increase in LDH levels at day 25 correlated with the gastrointestinal toxicity and liver dysfunction

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