Fig. 4

Diagnostic Performance Comparison of mNGS and Culture. a. Positive and negative cases in all, ID, NID and unknown group of mNGS and the culture, respectively. There were statistical differences between mNGS and culture of all (P < 0.01) and of ID group (P < 0.01), but no differences in NID and unknown group for the limited amounts(P > 0.05). b. Contingency tables showed the sensitivity and specificity of mNGS were 67.4 and 68.8%, while those of culture were 23.6 and 81.3%. mNGS increased the sensitivity in comparison with that of culture (P < 0.001) while there were no differences in specificity between them (P = 0.41). c. Pie chart demonstrated the positivity distribution of mNGS and culture for all samples from 3 groups. 53.21% were positive by mNGS, 4.59% by culture, 19.27% by both and 22.94% were both negative. Abbreviations: NPV, negative predictive values; PPV, positive predictive values