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Table 3 A-B Comparison of G12P[8] rotavirus strains with P[8] vaccine components of Rotarix and RotaTeq and other recent strains representing the P[8] lineages within the VP8* antigenic epitopes (defined in references [47, 50]). Amino acids substitutions within the studied strains are bolded and * indicates the amino acid is conserved

From: Genetic characterization of G12P[6] and G12P[8] rotavirus strains collected in six African countries between 2010 and 2014

A

P[8] Lineage

Country (Year) of isolation

8–1

8–2

8–3

100

146

148

150

188

190

192

193

194

195

180

183

113

114

115

116

125

131

Rotarix® (Vaccine)

I

USA (1989)

D

S

Q

E

S

T

N

L

N

N

T

A

N

P

V

D

S

S

RotaTeq® (Vaccine)

II

USA (1992)

*

*

*

*

*

*

*

*

*

D

*

*

*

*

*

*

N

R

GR079

III

Ethiopia (2016)

*

G

*

D

*

*

*

*

*

G

*

*

D

*

*

*

N

R

MRC-DPRU2144

IV

South Africa (2004)

*

G

*

*

*

*

D

*

*

S

*

*

*

*

*

*

*

R

MRC-DPRU2268

III

Ethiopia (2011)

*

G

*

D

*

*

*

*

*

G

*

*

D

*

*

*

N

R

#MRC-DPRU6219

III

Rwanda (2014)

*

G

*

*

*

*

*

*

*

G

*

*

*

*

*

*

N

R

#MRC-DPRU 2118

III

Togo (2011)

*

G

*

*

*

*

*

*

*

G

*

*

*

*

*

*

N

R

B

P[8] Lineage

Country (Year) of isolation

8–3

8–4

            

132

133

135

87

88

89

            

Rotarix® (Vaccine)

I

USA (1989)

N

D

V

N

T

N

            

RotaTeq® (Vaccine)

II

USA (1992)

*

*

*

*

*

*

            

GR079

III

Ethiopia (2016)

*

*

*

*

*

*

            

MRC-DPRU2144

IV

South Africa (2004)

*

*

*

*

*

*

            

MRC-DPRU2268

III

Ethiopia (2011)

*

*

*

*

*

*

            

MRC-DPRU6219

III

Rwanda (2014)

*

*

*

*

*

*

            

MRC-DPRU 2118

III

Togo (2011)

*

*

*

*

*

*

            
  1. #Strain represent itself
  2. MRCDPRU2268 represent three other strains from Ethiopia, one from Tanzania and one from Zambia