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Table 3 A-B Comparison of G12P[8] rotavirus strains with P[8] vaccine components of Rotarix and RotaTeq and other recent strains representing the P[8] lineages within the VP8* antigenic epitopes (defined in references [47, 50]). Amino acids substitutions within the studied strains are bolded and * indicates the amino acid is conserved

From: Genetic characterization of G12P[6] and G12P[8] rotavirus strains collected in six African countries between 2010 and 2014

A P[8] Lineage Country (Year) of isolation 8–1 8–2 8–3
100 146 148 150 188 190 192 193 194 195 180 183 113 114 115 116 125 131
Rotarix® (Vaccine) I USA (1989) D S Q E S T N L N N T A N P V D S S
RotaTeq® (Vaccine) II USA (1992) * * * * * * * * * D * * * * * * N R
GR079 III Ethiopia (2016) * G * D * * * * * G * * D * * * N R
MRC-DPRU2144 IV South Africa (2004) * G * * * * D * * S * * * * * * * R
MRC-DPRU2268 III Ethiopia (2011) * G * D * * * * * G * * D * * * N R
#MRC-DPRU6219 III Rwanda (2014) * G * * * * * * * G * * * * * * N R
#MRC-DPRU 2118 III Togo (2011) * G * * * * * * * G * * * * * * N R
B P[8] Lineage Country (Year) of isolation 8–3 8–4             
132 133 135 87 88 89             
Rotarix® (Vaccine) I USA (1989) N D V N T N             
RotaTeq® (Vaccine) II USA (1992) * * * * * *             
GR079 III Ethiopia (2016) * * * * * *             
MRC-DPRU2144 IV South Africa (2004) * * * * * *             
MRC-DPRU2268 III Ethiopia (2011) * * * * * *             
MRC-DPRU6219 III Rwanda (2014) * * * * * *             
MRC-DPRU 2118 III Togo (2011) * * * * * *             
  1. #Strain represent itself
  2. MRCDPRU2268 represent three other strains from Ethiopia, one from Tanzania and one from Zambia