Combination of Sequential Organ Failure Assessment (SOFA) score and Charlson Comorbidity Index (CCI) could predict the severity and prognosis of candidemia more accurately than the Acute Physiology, Age, Chronic Health Evaluation II (APACHE II) score

Table 3 Univariate and multivariate analyses among candidemia patients for 30-day death

Variables	Univariate analysis			Multivariate analysis
	OR	95%CI	p-value	OR	95%CI	p-value
SOFA score≧5	10.3	3.3–32.1	< 0.001	6.5	1.6–26.4	0.008
APACHE II≧13	5.0	1.6–15.7	0.008
Echinocandin use as initial treatment	0.3	0.1–0.8	0.021
Alb < 2.3 g/dl	2.6	0.9–7.0	0.08
CRP≧6.1 mg/dl	2.7	1.0–7.3	0.081
Disturbance of consciousness	5.1	1.8–15.0	0.03
CCI≧3	6.6	1.9–22.2	0.002	4.9	1.1–23.2	0.043

*Alb Albumin, CCI the Charlson Comorbidity Index, CI Confidential interval, CRP C-reactive protein

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