Skip to main content

Table 2 Clinical presentation on day of tocilizumab administration

From: Effects of Tocilizumab in COVID-19 patients: a cohort study

Disease severity

n (%)

WHO Ordinal Scale

 8 (deceased)

0 (0.0)

 7 (invasive mechanical ventilation + organ support)

17 (28.3)

 6 (invasive mechanical ventilation)

9 (15.0)

 5 (non-invasive ventilation or high-flow oxygen)

9 (15.0)

 4 (oxygen by mask or nasal prongs)

24 (40.0)

 3 (hospitalized without oxygen therapy)

1 (1.7)

 1–2 (not hospitalized)

0 (0.0)

Temperature ≥ 38 °C

28 (46.7)

Heart rate ≥ 100 beats/min

34 (56.7)

Respiratory rate ≥ 30 breaths/min

36 (60.0)

Abnormal chest imaging

59 (98.3)

Vasopressor use

18 (30.0)

Renal replacement therapy

4 (6.7)

Use of paralytics

9 (15.0)

Proned

5 (8.3)

Room air

1 (1.7)

Nasal cannula

18 (30.0)

Venti-mask

3 (5.0)

Nonrebreather

7 (11.7)

High-flow nasal cannula

6 (10.0)

Non-Invasive Positive Pressure Ventilation

2 (3.3)

Invasive mechanical ventilation

23 (38.3)

ARDS

 Mild (201 < PaO2/FiO2 ≤ 300)

13 (21.7)

 Moderate (101 < PaO2/FiO2 ≤ 200)

21 (35.0)

 Severe (PaO2/FiO2 ≤ 100)

16 (26.7)

PaO2/FiO2, median (range)

166 (33–523)

SOFA score, median (range)

3 (0–11)

ICU care

45 (75.0)

Laboratory parameters

Median (range)

Reference values

Number of patients with available data

 White blood cell count, ×109/L

9 (2.7–29.6)

4.0–10.5

51

 Absolute neutrophil count, ×109/L

6.85 (1.8–26.8)

2.0–6.0

49

 Absolute lymphocyte count, ×109/L

0.8 (0.2–2.6)

1.1–2.7

48

 Neutrophil-to-lymphocyte ratio (NLR)

7.56 (2.25–62)

0.88-4a

48

 Hemoglobin, g/dL

12.7 (9–15.9)

11.1–14.6

51

 RDW-CV, %

14 (11.6–18.3)

11–15

51

 Platelets, ×109/L

240 (101–513)

140–400

49

 Sodium, mmol/L

135 (123–148)

135–145

53

 CO2, mmol/L

24 (11–36)

22–30

53

 AST, U/L

70.5 (25–711)

15–46

46

 ALT, U/L

51.5 (6–242)

9–52

46

 Total bilirubin

0.65 (0.2–2.4)

0.2–1.3

48

 Creatinine, mg/dL

0.88 (0.4–4.58)

0.66–1.25

53

 Interleukin-6, pg/mL

133.9 (8.73–2160.69)

none

26

 C-reactive protein, mg/dL

24.2 (3.2–45)

0.0–0.9

49

 Erythrocyte sedimentation rate, mm/hr

50 (18–102)

0–10

24

 Lactate dehydrogenase, U/L

1333 (477–5089)

313–618

47

 Ferritin, ng/mL

1412.5 (45–29,304)

30–400

46

 Procalcitonin, ng/mL

0.40 (0.027–16.34)

0–0.08

33

 D-dimer, mcg/mL

1.3 (0.4- > 20)

0–0.49

33

 Troponin, ng/mL

0.104 (< 0.012–7.21)

0–0.034

15