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Table 2 Clinical presentation on day of tocilizumab administration

From: Effects of Tocilizumab in COVID-19 patients: a cohort study

Disease severity n (%)
WHO Ordinal Scale
 8 (deceased) 0 (0.0)
 7 (invasive mechanical ventilation + organ support) 17 (28.3)
 6 (invasive mechanical ventilation) 9 (15.0)
 5 (non-invasive ventilation or high-flow oxygen) 9 (15.0)
 4 (oxygen by mask or nasal prongs) 24 (40.0)
 3 (hospitalized without oxygen therapy) 1 (1.7)
 1–2 (not hospitalized) 0 (0.0)
Temperature ≥ 38 °C 28 (46.7)
Heart rate ≥ 100 beats/min 34 (56.7)
Respiratory rate ≥ 30 breaths/min 36 (60.0)
Abnormal chest imaging 59 (98.3)
Vasopressor use 18 (30.0)
Renal replacement therapy 4 (6.7)
Use of paralytics 9 (15.0)
Proned 5 (8.3)
Room air 1 (1.7)
Nasal cannula 18 (30.0)
Venti-mask 3 (5.0)
Nonrebreather 7 (11.7)
High-flow nasal cannula 6 (10.0)
Non-Invasive Positive Pressure Ventilation 2 (3.3)
Invasive mechanical ventilation 23 (38.3)
ARDS
 Mild (201 < PaO2/FiO2 ≤ 300) 13 (21.7)
 Moderate (101 < PaO2/FiO2 ≤ 200) 21 (35.0)
 Severe (PaO2/FiO2 ≤ 100) 16 (26.7)
PaO2/FiO2, median (range) 166 (33–523)
SOFA score, median (range) 3 (0–11)
ICU care 45 (75.0)
Laboratory parameters Median (range) Reference values Number of patients with available data
 White blood cell count, ×109/L 9 (2.7–29.6) 4.0–10.5 51
 Absolute neutrophil count, ×109/L 6.85 (1.8–26.8) 2.0–6.0 49
 Absolute lymphocyte count, ×109/L 0.8 (0.2–2.6) 1.1–2.7 48
 Neutrophil-to-lymphocyte ratio (NLR) 7.56 (2.25–62) 0.88-4a 48
 Hemoglobin, g/dL 12.7 (9–15.9) 11.1–14.6 51
 RDW-CV, % 14 (11.6–18.3) 11–15 51
 Platelets, ×109/L 240 (101–513) 140–400 49
 Sodium, mmol/L 135 (123–148) 135–145 53
 CO2, mmol/L 24 (11–36) 22–30 53
 AST, U/L 70.5 (25–711) 15–46 46
 ALT, U/L 51.5 (6–242) 9–52 46
 Total bilirubin 0.65 (0.2–2.4) 0.2–1.3 48
 Creatinine, mg/dL 0.88 (0.4–4.58) 0.66–1.25 53
 Interleukin-6, pg/mL 133.9 (8.73–2160.69) none 26
 C-reactive protein, mg/dL 24.2 (3.2–45) 0.0–0.9 49
 Erythrocyte sedimentation rate, mm/hr 50 (18–102) 0–10 24
 Lactate dehydrogenase, U/L 1333 (477–5089) 313–618 47
 Ferritin, ng/mL 1412.5 (45–29,304) 30–400 46
 Procalcitonin, ng/mL 0.40 (0.027–16.34) 0–0.08 33
 D-dimer, mcg/mL 1.3 (0.4- > 20) 0–0.49 33
 Troponin, ng/mL 0.104 (< 0.012–7.21) 0–0.034 15