Table 3 Urine versus cervical-samples: Concordance and agreement for hrHPV positivity and analytical accuracy of urine using cervical samples as comparator test
From: Urine collection in cervical cancer screening – analytical comparison of two HPV DNA assays
hrHPV result | Assay (total) | Cervical positive | Cervical negative | Kappad (95%CI) | Agreemente (%)(95%CI) | Sensitivity (%)(95%CI) | Specificity (%)(95%CI) | |
|---|---|---|---|---|---|---|---|---|
Any hrHPVa (14 types) | Cobas (n = 150) | Urine positive | 23 | 4 | ||||
Urine negative | 13 | 110 | 0.66 (0.51–0.81) | 88.7 (82.5–93.3) | 63.9 (46.2–79.2) | 96.5 (91.3–99.0) | ||
Clart (n = 150) | Urine positive | 16 | 9 | |||||
Urine negative | 15 | 110 | 0.47 (0.30–0.65) | 84.0 (77.1–89.5) | 51.6 (33.0–69.8) | 92.4 (86.1–96.5) | ||
HPV16/18b,f | Cobas (n = 150) | Urine positive | 4 | 2 | ||||
Urine negative | 11 | 133 | 0.34 (0.08–0.61) | 91.3 (85.6–95.3) | 26.7 (0.07–55.1) | 98.5 (94.8–99.8) | ||
Clart (n = 150) | Urine positive | 4 | 0 | |||||
Urine negative | 4 | 142 | 0.65 (0.34–0.97) | 97.3 (93.3–99.3) | 50.0 (15.7–84.3) | 100.0 (97.4–100.0) | ||
hrHPV otherc,f (12 types) | Cobas (n = 150) | Urine positive | 20 | 4 | ||||
Urine negative | 9 | 117 | 0.70 (0.55–0.85) | 91.3 (85.6–95.3) | 69.0 (49.2–84.7) | 96.7 (91.8–99.1) | ||
Clart (n = 150) | Urine positive | 12 | 9 | |||||
Urine negative | 17 | 112 | 0.38 (0.19–0.57) | 82.7 (75.6–88.4) | 41.4 (23.5–61.1) | 92.6 (86.3–96.5) |