Table 2 Urine versus vaginal self-samples: Concordance and agreement for hrHPV positivity and analytical accuracy of urine using vaginal self-samples as comparator test
From: Urine collection in cervical cancer screening – analytical comparison of two HPV DNA assays
hrHPV result | Assay (total) | Vaginal positive | Vaginal negative | Kappad (95%CI) | Agreemente (%)(95%CI) | Sensitivity (%)(95%CI) | Specificity (%)(95%CI) | |
|---|---|---|---|---|---|---|---|---|
Any hrHPVa (14 types) | Cobas (n = 150) | Urine positive | 26 | 1 | ||||
Urine negative | 18 | 105 | 0.66 (0.52–0.79) | 87.3 (80.9–92.2) | 59.1 (43.2–73.7) | 99.1 (94.9–99.7) | ||
Clart (n = 150) | Urine positive | 20 | 5 | |||||
Urine negative | 15 | 110 | 0.59 (0.43–0.75) | 86.7 (80.2–91.7) | 57.1 (39.4–73.7) | 95.7 (90.1–98.6) | ||
HPV16/18b,f | Cobas (n = 150) | Urine positive | 6 | 0 | ||||
Urine negative | 11 | 133 | 0.49 (0.23–0.74) | 92.7 (87.3–96.3) | 35.3 (14.2–61.7) | 100.0 (97.3–100.0) | ||
Clart (n = 150) | Urine positive | 4 | 0 | |||||
Urine negative | 5 | 141 | 0.60 (0.29–0.92) | 96.7 (92.4–98.9) | 44.4 (13.7–78.8) | 100 (97.4–100.0) | ||
hrHPV otherc,f (12 types) | Cobas (n = 150) | Urine positive | 23 | 1 | ||||
Urine negative | 15 | 111 | 0.68 (0.54–0.82) | 89.3 (83.3–93.8) | 60.5 (43.4–75.9) | 99.1 (95.1–99.9) | ||
Clart (n = 150) | Urine positive | 16 | 5 | |||||
Urine negative | 15 | 114 | 0.54 (0.36–0.71) | 86.7 (80.2–91.7) | 51.6 (33.1–69.8) | 95.8 (90.5–98.6) |