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Table 2 Prevalence of mutations associated to macrolide and fluoroquinolone resistance from 154 M. genitalium positive samples in Guangzhou, China, 2016–2018

From: Macrolide and fluoroquinolone associated mutations in Mycoplasma genitalium in a retrospective study of male and female patients seeking care at a STI Clinic in Guangzhou, China, 2016-2018

Gene

SNPa

Amino acid change

Frequency, % (No. of samples containing mutation(s) or wild type / No. of successfully sequenced samples)

23S rRNA

A-2071 → G

-b

13.8 (21/152)

A-2071 → T

–

13.2 (20/152)

A-2072 → G

–

38.8 (59/152)

A-2072 → C

–

0.7 (1/152)

Wild type

–

33.6 (51/152)

gyrA

G-285 → C

M-95 → I

0.7 (1/147)

G-286 → A

A-96 → T

0.7 (1/147)

Wild type

–

98.6 (145/147)

parC

C-234 → T

No change

0.7 (1/139)

G-241 → T

G-81 → T

0.7 (1/139)

A-247 → C

S-83 → R

2.2 (3/139)

G-248 → A

S-83 → N

5.8 (8/139)

G-248 → T

S-83 → I

56.8 (79/139)

T-249 → A

S-83 → R

1.4 (2/139)

G-259 → T

D-87 → Y

2.9 (4/139)

G-259 → A

D-87 → N

2.2 (3/139)

A-260 → G

D-87 → G

2.9 (4/139)

T-267 → C

No change

0.7 (1/139)

G-248 → T +

G-259 → T

S-83 → I + D-87 → Y

1.4 (2/139)

Wild type

–

22.3 (31/139)

  1. a Nucleotide positions in 23S rRNA and in gyrA and parC genes are given according to the M. genitalium G37 genome (GenBank accession no. NC_000908.2). SNP single-nucleotide polymorphism, rRNA ribosomal ribonucleic acid, b, no amino acid change