Prognostic value of pro-adrenomedullin and copeptin in acute infective endocarditis

Table 2 Biomarker levels in relation with major clinical features and mortality of IE patients §

	Pro-Adrenomedullin	^p-value	Procalcitonin	^p-value	Copeptin	^p-value	C-reactive protein	^p-value
Gender
Male	0.98 [0.11–13.09]	0.431	0.16 [0.03–19.89]	0.841	12.1 [2.14–389]	0.966	6.0 [0.10–69]	0.505
Female	1.27 [0.01–7.79]		0.17 [0.02–193.5]		15 [2.29–157.10]		6.2 [0.10–46]
Age
≤ 62.3	0.75 [0.11–13.09]	< 0.001	0.145 [0.02–19.89]	0.345	8.98 [2.14–389]	< 0.001	6.4 [0.10–29.8]	0.866
> 62.3	1.32 [0.01–7.79]		0.185 [0.04–193.5]		21.6 [2.49–202.10]		5.9 [0.10–69]
Embolic event
No	1.09 [0.05–13.09]	0.733	0.15 [0.02–19.89]	0.083	12.9 [2.14–389]	0.878	5.2 [0.10–69]	0.004
Yes	0.98 [0.01–7.79]		0.20 [0.02–193.5]		12.0 [2.29–233.40]		7.70 [0.10–29.8]
Surgery Indication
No	0.98 [0.01–7.79]	0.386	0.15 [0.04–193.5]	0.867	12.0 [2.49–157]	0.395	7.0 [0.5–46]	0.491
Yes	1.1 [0.11–13.09]		0.16 [0.02–19.89]		12.6 [2.14–389]		6.0 [0.10–69]
Surgery Performed
No	0.91 [0.01–7.79]	0.075	0.14 [0.04–193.5]	0.578	10.7 [2.49–233.4]	0.082	6.2 [0.1–46]	0.692
Yes	1.14 [0.11–13.09]		0.17 [0.02–19.89]		13.3 [2.14–389]		6.10 [0.10–69]
Hospital Mortality
No	0.95 [0.01–13.09]	< 0.001	0.15 [0.02–17.55]	0.006	11.7 [2.14–389]	< 0.001	5.9 [0.10–69]	0.056
Yes	1.94 [0.53–7.79]		0.32 [0.04–193.5]		35.7 [3.96–147.30]		7.2.2 [1.6–26.6]
1-Year Mortality
No	0.86 [0.01–13.0]	< 0.001	0.16 [0.02–17.5]	0.248	11.2 [2.14–389]	< 0.001	6.0 [0.10–69]	0.250
Yes	1.45 [0.05–7.79]		0.17 [0.04–193.5]		23.7 [3.70–225]		6.3 [0.10–27]

§ data are median [range]; ^ p-value was generated by Mann Whitney U-test; 151 Surg. Indication – 128 Surg. Performed