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Table 3 Multivariate Cox proportional hazard regression results for risk factors of the 90-day mortality

From: A risk score based on pediatric sequential organ failure assessment predicts 90-day mortality in children with Klebsiella pneumoniae bloodstream infection

Predictor

No. of deaths/total (%)

Adjusted HRa

(95% CI)

P value

Preterm birth

15/48 (31.3)

2.25 (1.04, 4.86)

0.04

Malignancies

5/11 (45.5)

2.36 (0.74, 7.56)

0.15

Prior hospitalization within 6 months

22/66 (33.3)

2.40 (1.12, 5.14)

0.02

Carbapenem-resistant isolate

21/71 (29.6)

2.13 (0.98, 4.61)

0.06

Source of bloodstream infection

 Primary or catheter-related

4/43 (9.3)

Ref

–

 Pneumonia

13/73 (17.8)

1.69 (0.51, 5.58)

0.39

 Intra-abdominal infection

16/30 (53.3)

6.75 (2.11, 21.57)

< 0.01

Organ failure

 Altered mental status

12/22 (54.5)

5.19 (2.50, 10.77)

< 0.01

 Respiratory failure

24/92 (26.1)

1.40 (0.61, 3.20)

0.42

 Shock/hypotension

15/43 (34.9)

2.41 (1.21, 4.82)

0.01

 Hepatic failure

24/77 (31.2)

2.90 (1.33, 6.35)

< 0.01

 Renal Failure

11/33 (33.3)

2.20 (1.02, 4.73)

0.04

 Coagulation disorder

23/58 (39.7)

4.54 (2.12, 9.72)

< 0.01

Laboratory predictorb

 Procalcitonin (ng/mL)

< 0.1

7/43 (16.3)

Ref

 

0.1–17

15/65 (23.1)

1.17 (0.43, 3.19)

0.76

> 17

11/38 (28.9)

1.72 (0.60, 4.91)

0.31

 C-reactive protein (mg/L)

< 8

5/47 (10.6)

Ref

 

8–77

9/60 (15)

1.48 (0.48, 4.53)

0.49

> 77

19/39 (48.7)

6.46 (2.26, 18.52)

< 0.01

 Albumin (g/L)

> 35

6/40 (15.0)

Ref

 

28–35

8/58 (13.8)

0.91 (0.32, 2.63)

0.86

< 28

19/48 (39.6)

3.32 (1.31, 8.40)

0.01

 Lactate (mmol/L)

< 2

17/101 (16.8)

Ref

 

≥ 2

16/45 (35.6)

3.44 (1.46, 8.11)

< 0.01

  1. HR hazard ratio
  2. aMultivariate adjustment was made for age, sex, admission ward and admission year
  3. bProcalcitonin, C-reactive protein and albumin were categorized into three strata by the boundaries of interquartile range (P25 and P75)