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Table 3 Multivariate Cox proportional hazard regression results for risk factors of the 90-day mortality

From: A risk score based on pediatric sequential organ failure assessment predicts 90-day mortality in children with Klebsiella pneumoniae bloodstream infection

Predictor No. of deaths/total (%) Adjusted HRa
(95% CI)
P value
Preterm birth 15/48 (31.3) 2.25 (1.04, 4.86) 0.04
Malignancies 5/11 (45.5) 2.36 (0.74, 7.56) 0.15
Prior hospitalization within 6 months 22/66 (33.3) 2.40 (1.12, 5.14) 0.02
Carbapenem-resistant isolate 21/71 (29.6) 2.13 (0.98, 4.61) 0.06
Source of bloodstream infection
 Primary or catheter-related 4/43 (9.3) Ref
 Pneumonia 13/73 (17.8) 1.69 (0.51, 5.58) 0.39
 Intra-abdominal infection 16/30 (53.3) 6.75 (2.11, 21.57) < 0.01
Organ failure
 Altered mental status 12/22 (54.5) 5.19 (2.50, 10.77) < 0.01
 Respiratory failure 24/92 (26.1) 1.40 (0.61, 3.20) 0.42
 Shock/hypotension 15/43 (34.9) 2.41 (1.21, 4.82) 0.01
 Hepatic failure 24/77 (31.2) 2.90 (1.33, 6.35) < 0.01
 Renal Failure 11/33 (33.3) 2.20 (1.02, 4.73) 0.04
 Coagulation disorder 23/58 (39.7) 4.54 (2.12, 9.72) < 0.01
Laboratory predictorb
 Procalcitonin (ng/mL) < 0.1 7/43 (16.3) Ref  
0.1–17 15/65 (23.1) 1.17 (0.43, 3.19) 0.76
> 17 11/38 (28.9) 1.72 (0.60, 4.91) 0.31
 C-reactive protein (mg/L) < 8 5/47 (10.6) Ref  
8–77 9/60 (15) 1.48 (0.48, 4.53) 0.49
> 77 19/39 (48.7) 6.46 (2.26, 18.52) < 0.01
 Albumin (g/L) > 35 6/40 (15.0) Ref  
28–35 8/58 (13.8) 0.91 (0.32, 2.63) 0.86
< 28 19/48 (39.6) 3.32 (1.31, 8.40) 0.01
 Lactate (mmol/L) < 2 17/101 (16.8) Ref  
≥ 2 16/45 (35.6) 3.44 (1.46, 8.11) < 0.01
  1. HR hazard ratio
  2. aMultivariate adjustment was made for age, sex, admission ward and admission year
  3. bProcalcitonin, C-reactive protein and albumin were categorized into three strata by the boundaries of interquartile range (P25 and P75)