Table 5 Association analysis of the HLA-DPB1 polymorphism (rs9277534) with dengue severity in Thailand
Genotype /allele | Number of subjects | DF vs DHF | DF vs DSS | DHF vs DSS | |||||
|---|---|---|---|---|---|---|---|---|---|
DF (n = 386) | DHF (n = 413) | DSS (n = 74) | P-valuea | OR (95%CI) | P-valuea | OR (95%CI) | P-valuea | OR (95%CI) | |
A/A | 47 (12.2%) | 64 (15.5%) | 6 (8.1%) | 0.09 | 1 | 0.43 | 1 | 0.25 | 1 |
A/G | 166 (43.0%) | 194 (47.0%) | 37 (50.0%) |  | 0.86 (0.54–1.35) |  | 1.75 (0.67–5.36) |  | 2.03 (0.79–6.16) |
G/G | 173 (44.8%) | 155 (37.5%) | 31 (41.9%) |  | 0.66 (0.42–1.04) |  | 1.40 (0.53–4.36) |  | 2.13 (0.82–6.54) |
A | 260 (33.7%) | 322 (39.0%) | 49 (33.1%) | 0.03 | 1 | 0.89 | 1 | 0.18 | 1 |
G | 512 (66.3%) | 504 (61.0%) | 99 (66.9%) |  | 0.79 (0.64–0.98) |  | 1.03 (0.69–1.52) |  | 1.29 (0.88–1.91) |
Dominant Model | |||||||||
 A/A | 47 (12.2%) | 64 (15.5%) | 6 (8.1%) | 0.18 | 1 | 0.32 | 1 | 0.09 | 1 |
 A/G, G/G | 339 (87.8%) | 349 (84.5%) | 68 (91.9%) |  | 0.76 (0.49–1.16) |  | 1.57 (0.63–4.67) |  | 2.08 (0.85–6.10) |
Recessive Model | |||||||||
 A/A, A/G | 213 (55.2%) | 258 (62.5%) | 43 (58.1%) | 0.04 | 1 | 0.64 | 1 | 0.48 | 1 |
 G/G | 173 (44.8%) | 155 (37.5%) | 31 (41.9%) |  | 0.74 (0.55–0.99) |  | 0.89 (0.52–1.51) |  | 1.20 (0.69–2.04) |
Overdominant Model | |||||||||
 A/A, G/G | 220 (57.0%) | 219 (53.0%) | 37 (50.0%) | 0.26 | 1 | 0.27 | 1 | 0.63 | 1 |
 A/G | 166 (43.0%) | 194 (47.0%) | 37 (50.0%) |  | 1.17 (0.87–1.56) |  | 1.32 (0.78–2.25) |  | 1.13 (0.67–1.91) |