Table 4 Association analysis of the CD27 polymorphism (rs2267966) with dengue severity in Thailand
Genotype /allele | Number of subjects | DF vs DHF | DF vs DSS | DHF vs DSS | |||||
|---|---|---|---|---|---|---|---|---|---|
DF (n = 384) | DHF (n = 409) | DSS (n = 73) | P-valuea | OR (95%CI) | P-valuea | OR (95%CI) | P-valuea | OR (95%CI) | |
A/A | 168 (43.8%) | 187 (45.7%) | 30 (41.1%) | 0.66 | 1 | 0.19 | 1 | 0.28 | 1 |
A/T | 165 (42.9%) | 176 (43.0%) | 38 (52.1%) | 0.96 (0.70–1.30) | 1.29 (0.74–2.26) | 1.35 (0.77–2.35) | |||
T/T | 51 (13.3%) | 46 (11.3%) | 5 (6.8%) | 0.81 (0.50–1.30) | 0.55 (0.16–1.54) | 0.68 (0.19–1.90) | |||
A | 501 (65.2%) | 550 (67.2%) | 98 (67.1%) | 0.39 | 1 | 0.66 | 1 | 0.98 | 1 |
T | 267 (34.8%) | 268 (32.8%) | 48 (32.9%) | 0.91 (0.74–1.13) | 0.92 (0.62–1.36) | 1.01 (0.68–1.48) | |||
Dominant Model | |||||||||
 A/A | 168 (43.8%) | 187 (45.7%) | 30 (41.1%) | 0.58 | 1 | 0.67 | 1 | 0.46 | 1 |
 A/T, T/T | 216 (56.2%) | 222 (54.3%) | 43 (58.9%) | 0.92 (0.69–1.23) | 1.11 (0.65–1.92) | 1.21 (0.71–2.08) | |||
Recessive Model | |||||||||
 A/A, A/T | 333 (86.7%) | 363 (88.7%) | 68 (93.2%) | 0.38 | 1 | 0.12 | 1 | 0.26 | 1 |
 T/T | 51 (13.3%) | 46 (11.3%) | 5 (6.8%) | 0.83 (0.53–1.29) | 0.48 (0.14–1.26) | 0.58 (0.17–1.53) | |||
Overdominant Model | |||||||||
 A/A, T/T | 219 (57.0%) | 233 (57.0%) | 35 (47.9%) | 0.98 | 1 | 0.15 | 1 | 0.15 | 1 |
 A/T | 165 (43.0%) | 176 (43.0%) | 38 (52.1%) | 1.00 (0.74–1.34) | 1.44 (0.84–2.46) | 1.43 (0.84–2.44) | |||