Table 3 Association analysis of the IFNL3 polymorphism (rs8099917) with dengue severity in Thailand
Genotype /allele | Number of subjects | DF vs DHF | DF vs DSS | DHF vs DSS | |||||
|---|---|---|---|---|---|---|---|---|---|
DF (n = 384) | DHF (n = 413) | DSS (n = 74) | P-valuea | OR (95%CI) | P-valuea | OR (95%CI) | P-valuea | OR (95%CI) | |
T/T | 342 (89.1%) | 365 (88.4%) | 67 (90.5%) | 0.95 | 1 | 1.00 | 1 | 1.00 | 1 |
G/T | 38 (9.9%) | 43 (10.4%) | 7 (9.5%) | 1.06 (0.65–1.73) | 0.94 (0.34–2.25) | 0.88 (0.32–2.10) | |||
G/G | 4 (1.0%) | 5 (1.2%) | 0 (0%) | 1.17 (0.25–5.95) | 0.56 (0.03–10.59) | 0.49 (0.03–9.01) | |||
T | 722 (94.0%) | 773 (93.6%) | 141(95.3%) | 0.72 | 1 | 0.55 | 1 | 0.43 | 1 |
G | 46 (6%) | 53 (6.4%) | 7 (4.7%) | 1.07 (0.70–1.65) | 0.78 (0.29–1.78) | 0.72 (0.27–1.64) | |||
Dominant Model | |||||||||
 T/T | 342 (89.1%) | 365 (88.4%) | 67 (90.5%) | 0.76 | 1 | 0.71 | 1 | 0.59 | 1 |
 G/T, G/G | 42 (10.9%) | 48 (11.6%) | 7 (9.5%) | 1.07 (0.67–1.70) | 0.85 (0.31–2.02) | 0.79 (0.29–1.86) | |||
Recessive Model | |||||||||
 T/T, G/T | 380 (99.0%) | 408 (98.8%) | 74 (100%) | 1.00 | 1 | 1.00 | 1 | 1.00 | 1 |
 G/G | 4 (1.0%) | 5 (1.2%) | 0 (0%) | 1.16 (0.25–5.91) | 0.57 (0.03–10.65) | 0.49 (0.03–9.11) | |||
Overdominant Model | |||||||||
 T/T,  G/G | 346 (90.1%) | 370 (89.6%) | 67 (90.5%) | 0.81 | 1 | 0.91 | 1 | 0.80 | 1 |
   G/T | 38 (9.9%) | 43 (10.4%) | 7 (9.5%) | 1.06(0.65–1.73) | 0.95 (0.34–2.28) | 0.89(0.32–2.13) | |||