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Table 2 Association between haematological parameters and sickle cell genotypes

From: Association between haematological parameters and sickle cell genotypes in children with Plasmodium falciparum malaria resident in Kisumu County in Western Kenya

Parameter

Dichotomised haematological outcome

Sickle cell genotype

OR

95% CI

P-value

Haemoglobin

Anaemia (Haemoglobin < 10 gdL-1)

HbAS

1.098

0.555–2.171

0.789

HbSS

0.310

0.101–0.956

0.041

Haematocrit

(Haematocrit < 33%)

HbAS

1.140

0.568–2.287

0.713

HbSS

0.318

0.128–0.793

0.014

RBC count

Erythrocytopaenia (RBC count < 3.8 × 1012 μL-1)

HbAS

0.706

0.235–2.123

0.100

HbSS

0.124

0.045–0.337

0.001

RDW

(< 12%)

HbAS

0.093

0.514–2.323

0.818

HbSS

2.993

0.952–9.409

0.061

MCV

Microcytosis (MCV < 76 fL)

HbAS

1.193

0.609–2.334

0.606

HbSS

2.094

0.854–5.137

0.106

Macrocytosis (MCV > 96 fL)

HbAS

1.058

0.107–10.452

0.962

HbSS

XXX

XXX

XXX

MCH

(< 25 Pg)

HbAS

0.763

0.263–2.219

0.620

HbSS

0.507

0.110–2.340

0.384

MCHC

(< 28 gdL-1)

HbAS

0.819

0.373–1.798

0.619

HbSS

0.325

0.118–0.892

0.029

WBC

Leucocytopaenia (WBC < 4 × 103 μL-1)

HbAS

0.131

0.011–1.528

0.105

HbSS

XXX

XXX

XXX

Leucocytosis (WBC > 10 × 103 μL-1)

HbAS

1.485

0.692–3.185

0.310

HbSS

9.283

3.167–27.210

0.001

Lymphocytes

Lymphoctopenia (Lymphocytes < 20%)

HbAS

0.625

0.265–1.473

0.283

HbSS

3.014

0.646–14.069

0.160

Lymphocytosis (Lymphocytes > 40%)

HbAS

0.607

0.180–2.052

0.422

HbSS

0.636

0.101–4.018

0.630

Monocytes

Monocytosis (Monocytes, > 10%)

HbAS

0.800

0.406–1.574

0.518

HbSS

0.319

0.123–0.830

0.019

Granulocytes

Granulocytopaenia (Granulocytes, < 30%)

HbAS

0.446

0.182–1.089

0.760

HbSS

2.201

0.459–10.547

0.324

Granulocytosis (Granulocytes, > 70%)

HbAS

0.941

0.354–2.503

0.903

HbSS

0.538

0.117–2.473

0.426

Platelets

Thrombocytopaenia (Platelet count < 150 × 103 μL-1)

HbAS

1.746

0.330–9.243

0.512

HbSS

XXX

XXX

XXX

Thrombocytosis (Platelet count > 300 × 103 μL-1)

HbAS

0.984

0.463–2.095

0.968

HbSS

XXX

XXX

XXX

MPV

Micro platelets (Platelets < 6 fL) Megathrombocytes (platelets> 12.3 fL)

HbAS

3.269

1.291–8.276

0.012

HbSS

4.781

0.355–6.470

0.238

NA

NA

NA

NA

PDW

(PDW, < 6%)

HbAS

0.932

0.286–3.035

0.907

HbSS

XXX

XXX

XXX

PCT

(PCT, < 0.22%)

HbAS

1.017

0.304–3.405

0.978

HbSS

0.552

0.220–13.900

0.718

  1. Children (n = 217) with acute febrile condition were categorized on the basis of sickle cell genotype (HbAA and HbSS). Odds ratios (OR) and 95% confidence intervals (CI) were determined using multivariate logistic regression analysis controlling for infection status. P-values in bold were statistically significant at P ≤ 0.05. XXX; did to run in the regression model. NA; not applicable. The reference groups in the logistic regression analysis were the homozygous wild-type genotypes (HbAA)