Incident tuberculosis disease in patients receiving biologic therapies in the Western Cape, South Africa from 2007 to 2018

Table 3 Cox proportional hazard model for variables associated with TB disease

	p-value	Hazard ratio [95% CI]
Age in years	0.35	1.009 [0.990–1.029]
Gender (female compared to male)	0.48	1.283 [0.641–2.570]
HIV status (HIV+ compared to HIV-)	0.01	3.000 [1.262–7.127]
IPT (IPT compared to no IPT)	0.32	1.524 [0.665–3.493]
Indication groups (IMID compared to HM)	0.42	1.568 [0.523–4.698]
Therapy groups (TNF-α inhibitors compared to non-TNF-α inhibitors)	0.62	1.233 [0.543–2.801]

IPT isoniazid preventative therapy, IMID immune mediated inflammatory disease, HM haematologic malignancy, TNF-α tumour necrosis factor-alpha

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