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Table 3 Major clinical manifestations of nervous system damage caused by EBV

From: Clinical characteristics of Epstein–Barr virus infection in the pediatric nervous system

Symptoms (Number of cases) Encephalitis/meningoencephalitis (n = 64) Myelitis (n = 2) EBV-HLH (n = 4) NS-PTLD (n = 1) ADEM (n = 3) GBS (n = 15)
Fever 60 2 4 1 3 4
Intracranial hypertension 37 0 1 0 1 2
Drowsy-lethargy 7 0 1 0 1 2
Coma 15 0 0 0 2 0
Convulsions (not including SE) 21 0 0 0 0 0
Status epilepticus 8 0 0 1 2 0
Mental symptoms 4 0 0 0 0 0
Central respiratory failure 8 0 1 0 1 0
Peripheral respiratory failure 1 1 0 0 0 3
Ataxia 3 0 0 1 1 0
Facial nerve 5 0 0 0 2 1
Oculomotor nerve 0 0 0 0 1 2
Bulbar paralysis 0 0 0 0 0 10
Pyramidal tract sign 24 2 0 0 1 0
Meningeal irritation sign 24 1 0 0 3 9
Increased muscle tension 13 1 0 0 2 0
Decreased muscle tension 7 2 0 0 2 9
Decreased muscle strength 9 2 0 0 2 15
Defecation disorder 0 1 0 0 0 3
Urination disorder 1 0 0 0 1 4
Nerve root pain 0 1 0 0 0 2
  1. SE Status epilepticus, EBV-HLH EBV-hemophagocytic lymphohistiocytosis, NS-PTLD NS-post-transplant lymphoproliferative disorder, ADEM acute disseminated encephalomyelitis, GBS Guillain–Barré Syndrome