Association between renal function and co-infection with Clonorchis sinensis and Helicobacter pylori: a cross-sectional study

Table 3 Association between co-infection with Clonorchis sinensis and Helicobacter pylori and eGFR in gender difference

Variables	Model 1^a			Model 2^b			Model 3^c
Variables	β	95% CI	p value	β	95% CI	p value	β	95% CI	p value
Male
Hp(−) + Cs(−)	reference	─	─	reference		─	reference	─	─
HP(+) + Cs(+)	−0.55	− 2.50, 1.40	0.556	− 0.35	(−2.28, 1.58)	0.723	0.68	−1.09, 2.45	0.452
HP(+) + Cs(−)	0.60	−1.10, 2.30	0.492	0.65	(−1.04, 2.34)	0.450	0.72	−0.83, 2.26	0.363
HP(−) + Cs(+)	0.15	−0.79, 1.10	0.750	0.28	(−0.66, 1.21)	0.561	0.48	−0.37, 1.35	0.268
Female
Hp(−) + Cs(−)	reference	─	─	reference		─	reference	─	─
HP(+) + Cs(+)	−10.25	−12.52, −7.98	< 0.001	−9.71	− 11.96, −7.47	< 0.001	−9.37	− 11.60, − 7.13	< 0.001
HP(+) + Cs(−)	−0.75	−2.91, 1.41	0.496	−0.82	− 2.95, 1.32	0.453	−0.69	− 2.79, 1.41	0.521
HP(−) + Cs(+)	−0.81	−1.85, 0.23	0.128	−72	−1.75, 0.31	0.171	−0.83	−1.84, 0.18	0.108

Abbreviations: eGFR Estimated glomerular filtration rate, CI Confidence interval, Hp Helicobacter pylori, Cs Clonorchis sinensis
^a Model 1 was adjusted for age, gender, history of hypertension and history of diabetes. Adjusted R² values for male and female are 0.317 and 0.540, respectively
^b Model 2 was adjusted for Model 1 + BMI, SBP and DBP. Adjusted R² values for male and female are 0.328 and 0.551, respectively
^c Model 3 was adjusted for Model 2 + ALT, AST, ALP, γ-GT, TC, TG, HDL, LDL, BUN, β₂-MB and UA. Adjusted R² values for male and female are 0.438 and 0.568, respectively

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