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Table 1 Antimicrobial agents and MIC breakpoints for rapidly growing mycobacteria

From: Pulmonary infection due to fluoroquinolone-resistant Mycolicibacterium fortuitum: a case report

 

MIC (μg/mL) for category

before treatment

after treatment

Susceptible

Intermediate

Resitant

Amikacin

≤16

32

≥64

< 1 (S)

4 (S)

Cefoxitin

≤16

32–64

≥128

32 (I)

6432 (I)

Ciprofloxacin

≤1

2

≥4

0.25 (S)

832 (R)

Clarithromycin

≤2

4

≥8

2 (> 32)a (R)

8 (> 32)a (R)

Imipenem

≤4

8–16

≥32

2 (S)

4 (S)

Linezolid

≤8

16

≥32

8 (S)

8 (S)

Meropenem

4

8–16

32

2 (S)

4 (S)

Moxifloxacin

≤1

2

≥4

0.25 (S)

8

Trimethoprim-sulfamethozazole

≤2/38

≥4/76

0.5/9.5 (S)

0.5/9.5 (S)

Tobramycin

≤2

4

≥8

16 (R)

32 (R)

Levofloxacinb

≤1

2

≥4

0.5 (S)

8 (R)

Sitafloxacinc

   

0.25

1

  1. The drug susceptibility test was performed in accordance with the standard operation procedures of the Clinical and Laboratory Standard Institute M24A-3
  2. Abbreviations: after treatment after treatment with clarithromycin and levofloxacin, before treatment before treatment with clarithromycin and levofloxacin, I intermediate, MIC minimum inhibitory concentration, R resistant, S susceptible
  3. aMIC after 3 days incubation priod (in parentheses, 14 days incubation priod)
  4. bthe MIC breakpoints of ciprofloxacin and levofloxacin are interchangeable
  5. creference value