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Table 2 Diagnostic performance of the RT-LAMP assay against that of the qRT-PCR assay in the simulated clinical human saliva, urine and serum samples (n = 24)

From: A reverse transcription loop-mediated isothermal amplification for broad coverage detection of Asian and African Zika virus lineages

  

qRT-PCR

Sensitivity [% (95% CIc)]

Specificity [% (95% CI)]

PPVd [% (95% CI)]

NPV e [% (95% CI)]

 

Resultsa, b

Pos [n (%)]

Neg [n (%)]

    

RT-LAMP

Pos

9 (37.5)

0 (0.0)

90.0 (59.6–98.2)

100.0 (78.5–100.0)

100.0 (70.1–100.0)

93.3 (70.2–98.8)

 

Neg

1 (4.2)

14 (58.3)

    
  1. a Agreement of results between RT-LAMP and qRT-PCR, κ = 0.913
  2. b Pos, positive; Neg, negative
  3. c CI, confidence interval
  4. d PPV, positive predictive value
  5. e NPV, negative predictive value
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BMC Infectious Diseases

ISSN: 1471-2334

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