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Table 2 Diagnostic performance of the RT-LAMP assay against that of the qRT-PCR assay in the simulated clinical human saliva, urine and serum samples (n = 24)

From: A reverse transcription loop-mediated isothermal amplification for broad coverage detection of Asian and African Zika virus lineages

   qRT-PCR Sensitivity [% (95% CIc)] Specificity [% (95% CI)] PPVd [% (95% CI)] NPV e [% (95% CI)]
  Resultsa, b Pos [n (%)] Neg [n (%)]     
RT-LAMP Pos 9 (37.5) 0 (0.0) 90.0 (59.6–98.2) 100.0 (78.5–100.0) 100.0 (70.1–100.0) 93.3 (70.2–98.8)
  Neg 1 (4.2) 14 (58.3)     
  1. a Agreement of results between RT-LAMP and qRT-PCR, κ = 0.913
  2. b Pos, positive; Neg, negative
  3. c CI, confidence interval
  4. d PPV, positive predictive value
  5. e NPV, negative predictive value