Table 2 Laboratory, radiology findings and treatment of four passages patients
Passage 1 (n = 1) | Passage 2 (n = 8) | Passage 3 (n = 23) | Passage 4 (n = 46) | p values | |
|---|---|---|---|---|---|
Laboratory findings | |||||
Blood count | |||||
White blood cell count, × 109/L | 4.60 | 6.51 (3.40–7.90) | 5.34 (2.30–14.10) | 5.21 (2.30–12.80) | 0.04 |
Neutrophil count, × 109/L | 3.40 | 4.86 (1.60–11.40) | 3.61 (1.10–12.20) | 3.48 (1.00–7.70) | 0.02 |
Neutrophil percentage | 72.60 | 74.65 (45.80–91.60) | 67.60 (28.40–87.10) | 66.79 (34.60–84.50) | 0.03 |
Lymphocyte count, ×109/L | 1.50 | 0.79 (0.40–1.10) | 1.12 (0.50–3.10) | 1.59 (0.60–2.90) | 0.002 |
Lymphocyte percentage | 22.00 | 12.14 (7.10–49.00) | 20.97 (8.60–59.20) | 30.51 (10.70–53.10) | 0.02 |
Platelet count, ×109/L | 164.00 | 141.00 (65.00–214.00) | 153.50 (57.00–272.00) | 172.50 (63.00–311.00) | 0.04 |
Prothrombin time, s | 12.40 | 14.12 (11.50–16.00) | 12.61 (11.40–14.10) | 13.27 (11.30–16.90) | 0.81 |
Red blood cell count(> 5.1 × 1012/L), No. (%) | 0 | 2 (25.00) | 2 (8.70) | 1 (2.17) | 0.04 |
Blood chemistry Renal function | |||||
Blood urea nitrogen (< 2.8 mmol/L), No. (%) | 0 | 2 (25.00) | 5 (21.74) | 4 (8.70) | 0.23 |
Creatinine (> 123 μmol/L), No. (%) | 0 | 0 | 1 (4.35) | 0 | 0.30 |
Fibrinogen (> 4 g/L), No. (%) | 2.64 | 3.08 (1.94–5.40) | 2.75 (1.46–4.57) | 2.34 (1.51–4.66) | 0.26 |
Calcium, (< 2.1 mmol/L), No. (%) | 0 | 2 (25.00) | 2 (8.70) | 2 (4.35) | 0.13 |
Magnesium, (< 0.75 mmol/L), No. (%) | 0 | 2 (25.00) | 3 (13.04) | 7 (15.22) | 0.70 |
Sodium, (< 135 mmol/L), No. (%) | 0 | 4 (50.00) | 6 (26.09) | 6 (13.04) | 0.04 |
Chlorine,(> 108 mmol/L), No. (%) | 0 | 0 | 1 (4.35) | 2 (4.35) | 0.83 |
Liver function | |||||
Alanine aminotransferase (> 40 U/L), No. (%) | 0 | 3 (37.50) | 11 (47.83) | 14 (30.43) | 0.37 |
Aspartate aminotransferase, (> 40 U/L), No. (%) | 0 | 3 (37.50) | 9 (39.13) | 9 (19.57) | 0.18 |
Total bilirubin (> 28 μmol/L), No. (%) | 0 | 2 (25.00) | 1 (4.34) | 1 (2.17) | 0.03 |
Prealbumin levels (< 180 ng/L), No. (%) | 0 | 5 (62.5) | 10 (43.48) | 9 (19.57) | 0.02 |
Albumin (< 35 g/L), No. (%) | 0 | 1 (12.50) | 0 (0.00) | 0 (0.00) | 0.01 |
Lactate dehydrogenase, (> 245 U/L), No. (%) | 1 | 8 (100) | 11 (47.83) | 13 (28.26) | < 0.001 |
Infection related biomarker | |||||
Erythrocyte sedimentation rate (> 15 mm/h), No. (%) | 0 | 6 (75.00) | 7 (30.43) | 11 (23.91) | 0.02 |
C-reactive protein (> 10 ng/L), No. (%) | 1 | 8 (100.00) | 5 (21.74) | 7 (15.22) | < 0.001 |
Procalcitonin (> 0.05 ng/mL), No. (%) | 0 | 0 (0.00) | 1 (4.34) | 0 (0.00) | 0.30 |
Radiology findings | |||||
Ground glass opacity, No. (%) | 1 (100.00) | 8 (100.00) | 15 (65.22) | 16 (34.78) | < 0.001 |
Treatment | |||||
Antiviral | 1 (100.00) | 8 (100.00) | 23 (100.00) | 46 (100.00) | |
Antibiotics | 1 (100.00) | 8 (100.00) | 6 (26.09) | 9 (19.57) | 0.001 |
Oxygen inhalation | 1 (100.00) | 8 (100.00) | 16 (69.57) | 19 (41.30) | 0.002 |
Severe and critical | |||||
Severed patient, No. (%) | 0 (0.00) | 4 (50.00) | 2 (8.70) | 2 (4.35) | < 0.001 |
Critical patient, No. (%) | 0 (0.00) | 0 (0.00) | 1 (4.35) | 0 (0.00) | 0.30 |
Days in ICU, median, IQR | 0 | 6.5 (3.5–9.5) | 5 (3–8) | 3 (2–4) | 0.22 |